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Histone Methyltransferase

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Histone Methyltransferase

Chemical Structure Cat. No. Product Name CAS No.
HLCL-61 Chemical Structure
 BCP24221 HLCL-61 586395-74-6
HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.
Chemical Structure
UNC669 Chemical Structure
 BCP27815 UNC669 1314241-44-5
UNC 669 is a potent antagonist of L3MBTL1(IC50=4.2 uM) and L3MBTL3(IC50=3.1 uM).
EPZ-020411 Chemical Structure
 BCP29978 EPZ-020411 1700663-41-7
EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
EPZ020411 HCl Chemical Structure
 BCP29979 EPZ020411 HCl 2070015-25-5
EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
SGC2085 Chemical Structure
 BCP25834 SGC2085 1821908-48-8
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 50 nM.
AZ505 ditrifluoroacetate Chemical Structure
 BCP29703 AZ505 ditrifluoroacetate 1035227-44-1
AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM.
AZ-505 Chemical Structure
 BCP20970 AZ-505 1035227-43-0
AZ505 is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM.
GSK3326595  Chemical Structure
 BCP25738 GSK3326595  1616392-22-3
GSK3326595 is a PRMT5 inhibitor extracted from patent WO 2016022605 A1, Formula A.
EI1 Chemical Structure
 BCP23699 EI1 1418308-27-6
EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
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