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Chemical Structure Cat. No. Product Name CAS No.
GDC-0575 dihydrochloride Chemical Structure
BCP29768 GDC-0575 dihydrochloride 1657014-42-0
GDC-0575 dihydrochloride is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
SAR-020106 Chemical Structure
BCP29578 SAR-020106 1184843-57-9
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM.
AZD7762 HCl Chemical Structure
BCP25387 AZD7762 HCl 1246094-78-9
AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and potentiating DNA-targeted therapies.
GDC-0575 Chemical Structure
BCP20675 GDC-0575 1196541-47-5
GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
Prexasertib Mesylate Hydrate Chemical Structure
BCP24330 Prexasertib Mesylate Hydrate 1234015-57-6
Prexasertib is a Chk1 inhibitor potentially for the treatment of ovarian cancer and breast cancer.
GDC0575 Chemical Structure
BCP25421 GDC0575 2097938-64-0
GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective CHK1 inhibitor.
PF-477736 Chemical Structure
BCP02213 PF-477736 952021-60-2
PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively.
Chk2 Inhibitor II Chemical Structure
BCP09077 Chk2 Inhibitor II 516480-79-8
BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor.
CCT245737 Chemical Structure
BCP18991 CCT245737 1489389-18-5
CCT245737 is a potent, ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM.
SCH900776 S-isomer Chemical Structure
BCP06478 SCH900776 S-isomer 891494-64-7
SCH900776 S-isomer is the S-isomer of SCH900776.SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 500-fold selectivity against Chk2.
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