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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
ZD-4190 Chemical Structure
 BCP30854 ZD-4190 413599-62-9
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.
LUT-014 Chemical Structure
 BCP30636 LUT-014 2274819-46-2
LUT014 is a topical B-Raf Inhibitor, a proprietary, first-in-class, small molecule allowing administration of EGFR (Epidermal Growth Factor Receptor) Inhibitors to patients without interruptions caused by typical cutaneous side effects
Necitumumab Chemical Structure
 BCP30497 Necitumumab 906805-06-9
Necitumumab is a recombinant human IgG1 monoclonal antibody used as an antineoplastic.
TAS6417 Chemical Structure
 BCP30474 TAS6417 1661854-97-2
TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
Lazertinib Chemical Structure
 BCP30440 Lazertinib 1903008-80-9
Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.
AST2818 mesylate Chemical Structure
 BCP30340 AST2818 mesylate 2130958-55-1
AST2818 mesylate is an EGFR inhibitor.
AST2818 Chemical Structure
 BCP30339 AST2818 1869057-83-9
AST2818 is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.
NRC-2694 Chemical Structure
 BCP30237 NRC-2694 936446-61-6
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.
AZD-8931 Difumaric acid Chemical Structure
 BCP24789 AZD-8931 Difumaric acid 1196531-39-1
AZD-8931 is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.
TX-1918 Chemical Structure
 BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
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