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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
AST5902 Chemical Structure
 BCP39664 AST5902 AST5902
Alflutinib is mainly metabolized via CYP3A4 to form its active metabolite AST5902.
JND3229 Chemical Structure
 BCP38649 JND3229 2260886-64-2
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
Almonertinib Chemical Structure
 BCP38312 Almonertinib 1899921-05-1
Almonertinib is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.
Epertinib hydrochloride Chemical Structure
 BCP37982 Epertinib hydrochloride 2071195-74-7
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4. It shows potent antitumor activity.
TX1-85-1 Chemical Structure
 BCP37896 TX1-85-1 1603845-32-4
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).
PD089828 Chemical Structure
 BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
EGFR-IN-8 Chemical Structure
 BCP37628 EGFR-IN-8 2407957-87-1
EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48.
BDTX-189 Chemical Structure
 BCP37532 BDTX-189 2414572-47-5
BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
CH7233163 Chemical Structure
 BCP37295 CH7233163 CH7233163
CH7233163 overcomes osimertinib resistant EGFR-Del19/T790M/C797S mutation
Pyrotinib Racemate Chemical Structure
 BCP36485 Pyrotinib Racemate 1246089-97-3
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
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