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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
AZD-8931 Difumaric acid Chemical Structure
BCP24789 AZD-8931 Difumaric acid 1196531-39-1
AZD-8931 is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.
TX-1918 Chemical Structure
BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
RX-518 Chemical Structure
BCP19075 RX-518 1660963-42-7
RX518 is an epidermal growth factor receptor (EGFR) inhibitor.
JNJ-26483327 Chemical Structure
BCP28258 JNJ-26483327 807640-87-5
JNJ-26483327 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
NT113 Chemical Structure
BCP29708 NT113 1398833-56-1
NT-113 is an irreversible pan-ERBB inhibitor, with IC50s of 0.4, 4.35, 4.18 and 2.08 nM for EGFR, EGFRT790M, ERBB2/HER2 and ERBB4/HER4, respectively, exhibiting anti-glioma activities.
Mutant EGFR inhibitor Chemical Structure
BCP23941 Mutant EGFR inhibitor 1421373-62-7
Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.
Rindopepimut Chemical Structure
BCP23858 Rindopepimut 1108208-65-6
CDX-110 is an investigational immunotherapy that targets the tumor specific molecule EGFRvIII, a functional variant of the epidermal growth factor receptor (EGFR), which is a protein that has been well validated as a target for cancer therapy.
Nimotuzumab Chemical Structure
BCP25910 Nimotuzumab 828933-51-3;780758-10-3
Nimotuzumab is a humanized monoclonal antibody and binds with optimal affinity and high specificity to the extracellular region of EGFR (epidermal growth factor receptor).
AV-412 Tosylate Chemical Structure
BCP23783 AV-412 Tosylate 451493-31-5
AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
RG-14620 Chemical Structure
BCP20770 RG-14620 136831-49-7
RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
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