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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
PF-06459988 Chemical Structure
 BCP44108 PF-06459988 1428774-45-1
PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity.
AZ7550 hydrochloride Chemical Structure
 BCP43207 AZ7550 hydrochloride 2309762-40-9
AZ-7550 is a metabolite of Osimertinib.
AST5902 Chemical Structure
 BCP39664 AST5902 AST5902
Alflutinib is mainly metabolized via CYP3A4 to form its active metabolite AST5902.
JND3229 Chemical Structure
 BCP38649 JND3229 2260886-64-2
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
Almonertinib Chemical Structure
 BCP38312 Almonertinib 1899921-05-1
Almonertinib is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.
Epertinib hydrochloride Chemical Structure
 BCP37982 Epertinib hydrochloride 2071195-74-7
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4. It shows potent antitumor activity.
TX1-85-1 Chemical Structure
 BCP37896 TX1-85-1 1603845-32-4
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).
PD089828 Chemical Structure
 BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
EGFR-IN-8 Chemical Structure
 BCP37628 EGFR-IN-8 2407957-87-1
EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48.
BDTX-189 Chemical Structure
 BCP37532 BDTX-189 2414572-47-5
BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
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