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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
RX-518 Chemical Structure
 BCP19075 RX-518 1660963-42-7
RX518 is an epidermal growth factor receptor (EGFR) inhibitor.
JNJ-26483327 Chemical Structure
 BCP28258 JNJ-26483327 807640-87-5
JNJ-26483327 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
NT113 Chemical Structure
 BCP29708 NT113 1398833-56-1
NT-113 is an irreversible pan-ERBB inhibitor, with IC50s of 0.4, 4.35, 4.18 and 2.08 nM for EGFR, EGFRT790M, ERBB2/HER2 and ERBB4/HER4, respectively, exhibiting anti-glioma activities.
Mutant EGFR inhibitor Chemical Structure
 BCP23941 Mutant EGFR inhibitor 1421373-62-7
Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.
Rindopepimut Chemical Structure
 BCP23858 Rindopepimut 1108208-65-6
CDX-110 is an investigational immunotherapy that targets the tumor specific molecule EGFRvIII, a functional variant of the epidermal growth factor receptor (EGFR), which is a protein that has been well validated as a target for cancer therapy.
Nimotuzumab Chemical Structure
 BCP25910 Nimotuzumab 828933-51-3;780758-10-3
Nimotuzumab is a humanized monoclonal antibody and binds with optimal affinity and high specificity to the extracellular region of EGFR (epidermal growth factor receptor).
AV-412 Tosylate Chemical Structure
 BCP23783 AV-412 Tosylate 451493-31-5
AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
RG-14620 Chemical Structure
 BCP20770 RG-14620 136831-49-7
RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
Pyrotinib Chemical Structure
 BCP29458 Pyrotinib 1269662-73-8
Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.
AG-494 Chemical Structure
 BCP29134 AG-494 133550-35-3
AG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 µM in HT-22 cells
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