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EGFR

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EGFR

Chemical Structure Cat. No. Product Name CAS No.
AG556 Chemical Structure
 BCP35023 AG556 133550-41-1
AG-556 is an epidermal growth factor receptor (EGFR) kinase inhibitor.
Mobocertinib succinate Chemical Structure
 BCP33315 Mobocertinib succinate 2389149-74-8
Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.
Norcantharidin Chemical Structure
 BCP25426 Norcantharidin 29745-04-8
Norcantharidin is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
ONO7475 Chemical Structure
 BCP33232 ONO7475 1646839-59-9
ONO-7475 is a potent and orally active Axl/Mer inhibitor. ONO-7475 targets and binds to both Axl and Mer, and prevents their activity.
Tyrphostin AG30 Chemical Structure
 BCP32895 Tyrphostin AG30 122520-79-0
Tyrphostin AG30 is an antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.
JBJ-04-125-02 Chemical Structure
 BCP32863 JBJ-04-125-02 2060610-53-7
JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.
EGFR inhibitor Chemical Structure
 BCP32602 EGFR inhibitor 879127-07-8
EGFR inhibitor is an EGFR inhibitor. It directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
Tarloxotinib bromide Chemical Structure
 BCP32560 Tarloxotinib bromide 1636180-98-7
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor.
Butein Chemical Structure
 BCP31369 Butein 21849-70-7
Butein is a chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
BI-4020 Chemical Structure
 BCP31931 BI-4020 BI4020
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). BI-4020 also shows activity against EGFR wt (IC50=190 nM). BI-4020 shows high kinome selectivity and good DMPK properties.
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