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Raw Materials
EGFR
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP38649 | JND3229 New | 2260886-64-2 |
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
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BCP38312 | Almonertinib New | 1899921-05-1 |
Almonertinib is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.
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BCP37982 | Epertinib hydrochloride New | 2071195-74-7 |
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4. It shows potent antitumor activity.
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BCP37896 | TX1-85-1 New | 1603845-32-4 |
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).
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BCP37851 | PD089828 New | 179343-17-0 |
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
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BCP37628 | EGFR-IN-8 New | 2407957-87-1 |
EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48.
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BCP37532 | BDTX-189 New | 2414572-47-5 |
BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
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BCP37295 | CH7233163 New | CH7233163 |
CH7233163 overcomes osimertinib resistant EGFR-Del19/T790M/C797S mutation
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BCP36485 | Pyrotinib Racemate New | 1246089-97-3 |
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
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BCP35916 | TAS6417 HCl New | TAS6417HCl |
TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
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