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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
GNF4877 Chemical Structure
BCP31624 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM.
MAZ51 Chemical Structure
BCP31595 MAZ51 163655-37-6
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.
GMB-475 Chemical Structure
BCP31499 GMB-475 GMB-475
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.
Theliatinib Chemical Structure
BCP31409 Theliatinib 1353644-70-8
Theliatinib is a potent, ATP-competitive and highly selective EGFR inhibitor, significantly inhibits phosphorylation of EGFR (p-EGFR) and its downstream targets, AKT and ERK (p-AKT and p-ERK), with anti-tumor activity. Theliatinib (HMPL-309) shows a Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively.
PLX5622 Chemical Structure
BCP31350 PLX5622 1303420-67-8
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals.
JND3229 Chemical Structure
BCP31299 JND3229 JND3229
JND3229 is a new highly potent EGFRC797S reversible inhibitor with IC50 value of 5.8 nM, and also potently suppressed EGFRL858R/T790M and EGFRWT with IC50 values of 30.5 and 6.8 nM.
IDF-11774 Chemical Structure
BCP31295 IDF-11774 1429054-28-3
IDF-11774 is a potent, orally bioavailable HIF-1 inhibitor.
ILK-IN-1 Chemical Structure
BCP23690 ILK-IN-1 1333146-24-9
OSU-T315 (1,5-regioisomer) is a potent and specific integrin-linked kinase (ILK) inhibitor.
cis-Pralsetinib Chemical Structure
BCP31224 cis-Pralsetinib 2097132-93-7
cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.
JNJ-38158471 Chemical Structure
BCP21621 JNJ-38158471 951151-97-6
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM.
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