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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
EGFR inhibitor Chemical Structure
BCP32602 EGFR inhibitor 879127-07-8
EGFR inhibitor is an EGFR inhibitor. It directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
FM-479 Chemical Structure
BCP32593 FM-479 2226521-64-6
FM-479 is a negative control for FM-381 (GLXC-09922).
Tarloxotinib bromide Chemical Structure
BCP32560 Tarloxotinib bromide 1636180-98-7
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor.
TCJL37 Chemical Structure
BCP32555 TCJL37 1258294-34-6
TCJL-37 is a potent TYK2 inhibitor.
MS4078 Chemical Structure
BCP32539 MS4078 2229036-62-6
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 19 nM for binding affinity to ALK.
Vedolizumab Chemical Structure
BCP26256 Vedolizumab 943609-66-3
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
Ramucirumab Chemical Structure
BCP26258 Ramucirumab 947687-13-0
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D.
Btk inhibitor 1 R enantiomer hydrochloride Chemical Structure
BCP30305 Btk inhibitor 1 R enantiomer hydrochloride 1553977-42-6
Btk inhibitor 1R enantiomer Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.
Butein Chemical Structure
BCP31369 Butein 21849-70-7
Butein is a chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
BI-4020 Chemical Structure
BCP31931 BI-4020 BI4020
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). BI-4020 also shows activity against EGFR wt (IC50=190 nM). BI-4020 shows high kinome selectivity and good DMPK properties.
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