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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
cis-Pralsetinib Chemical Structure
 BCP31224 cis-Pralsetinib 2097132-93-7
cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.
JNJ-38158471 Chemical Structure
 BCP21621 JNJ-38158471 951151-97-6
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM.
Tyrphostin AG 490 Chemical Structure
 BCP21393 Tyrphostin AG 490 134036-52-5
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
TG 100572 Hydrochloride Chemical Structure
 BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
Tyrphostin A46 Chemical Structure
 BCP31172 Tyrphostin A46 122520-85-8
Tyrphostin A46 is an inhibitor of EGF receptor kinase with an IC50 value of 10 μM in the human epidermoid carcinoma cell line A431.
Glumetinib Chemical Structure
 BCP31155 Glumetinib 1642581-63-2
Glumetinib is a potent and highly selective c-Met kinase inhibitor with an IC50 of 0.42 nM. Glumetinib shows antitumor activity and a superior safety margin.
Lucitanib hydrochloride Chemical Structure
 BCP21230 Lucitanib hydrochloride 1058137-84-0
Lucitanib is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
PD 166285 dihydrochloride Chemical Structure
 BCP22349 PD 166285 dihydrochloride 212391-63-4
PD-166285 is a potent and broadly active protein tyrosine kinase inhibitor.
CP-547632 Chemical Structure
 BCP22974 CP-547632 252003-65-9
CP-547632 is a potent inhibitor of the VEGFR2 and FGF2 kinases with IC50s of 11 and 9 nM, respectively.
SAR348830 Chemical Structure
 BCP31069 SAR348830 1462949-64-9
SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).
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