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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
UNC2541 Chemical Structure
BCP33929 UNC2541 1612782-86-1
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
BO-264 Chemical Structure
BCP33848 BO-264 2408648-20-2
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity.
CH7057288 Chemical Structure
BCP33760 CH7057288 2095616-82-1
CH7057288 is a potent and selective TRK inhibitor.
PF-06826647 Chemical Structure
BCP33615 PF-06826647 2127109-84-4
PF-06826647(Tyk2-IN-8) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.
Mobocertinib succinate Chemical Structure
BCP33315 Mobocertinib succinate 2389149-74-8
Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.
Norcantharidin Chemical Structure
BCP25426 Norcantharidin 29745-04-8
Norcantharidin is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
SU 5205 Chemical Structure
BCP25520 SU 5205 3476-86-6
SU 5205 is a VEGFR2 inhibitor.
PT2399 Chemical Structure
BCP25901 PT2399 1672662-14-4
PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo.
ONO7475 Chemical Structure
BCP33232 ONO7475 1646839-59-9
ONO-7475 is a potent and orally active Axl/Mer inhibitor. ONO-7475 targets and binds to both Axl and Mer, and prevents their activity.
Vandetanib trifluoroacetate Chemical Structure
BCP33121 Vandetanib trifluoroacetate 338992-53-3
Vandetanib trifluoroacetate is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
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