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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
BI-4020 Chemical Structure
BCP31931 BI-4020 BI4020
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). BI-4020 also shows activity against EGFR wt (IC50=190 nM). BI-4020 shows high kinome selectivity and good DMPK properties.
JBJ-04-125-02 Chemical Structure
BCP31914 JBJ-04-125-02 2140807-05-0
JBJ-04-125-02 is a single agent can inhibit cell proliferation and EGFRL858R/T790M/C797S signaling in vitro and in vivo.
Alofanib Chemical Structure
BCP31905 Alofanib 1612888-66-0
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity.
cFMS Receptor Inhibitor II Chemical Structure
BCP31859 cFMS Receptor Inhibitor II 959860-85-6
cFMS Receptor Inhibitor II is a cFMS inhibitor.
Gusacitinib HCl Chemical Structure
BCP31676 Gusacitinib HCl GusacitinibHCl
Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
Gusacitinib Chemical Structure
BCP31675 Gusacitinib 1425381-60-7
Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
GNF4877 Chemical Structure
BCP31624 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM.
MAZ51 Chemical Structure
BCP31595 MAZ51 163655-37-6
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.
GMB-475 Chemical Structure
BCP31499 GMB-475 GMB-475
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.
Theliatinib Chemical Structure
BCP31409 Theliatinib 1353644-70-8
Theliatinib is a potent, ATP-competitive and highly selective EGFR inhibitor, significantly inhibits phosphorylation of EGFR (p-EGFR) and its downstream targets, AKT and ERK (p-AKT and p-ERK), with anti-tumor activity. Theliatinib (HMPL-309) shows a Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively.
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