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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
Pirtobrutinib Chemical Structure
 BCP42730 Pirtobrutinib 2101700-15-4
Pirtobrutinib is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent.
JH-X-119-01 Chemical Structure
 BCP42501 JH-X-119-01 2227368-54-7
Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor.
BD750 Chemical Structure
 BCP42671 BD750 892686-59-8
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
SB1317 Chemical Structure
 BCP42651 SB1317 1204918-72-8
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
NBI-31772 Chemical Structure
 BCP42327 NBI-31772 374620-70-9
NBI-31772 is an potent insulin-like growth factor-1 binding protein (IGFBP) inhibitor.
TPX-0131 Chemical Structure
 BCP42131 TPX-0131 2648641-36-3
TPX-0131 is a CNS-penetrant, next-generation ALK inhibitor that has potency against wild-type ALK and a spectrum of acquired resistance mutations, especially the G1202R solvent front mutation and compound mutations, for which there are currently no effective therapies.
Norleual Chemical Structure
 BCP41927 Norleual 334994-34-2
Norleual, an angiotensin IV analog, competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes. It is also an AT4 receptor antagonist, which disrupts LTP stabilization.
AZ Dyrk1B 33 Chemical Structure
 BCP41848 AZ Dyrk1B 33 1679330-37-0
AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor.
CNX-500 Chemical Structure
 BCP40963 CNX-500 1202758-21-1
CNX-500 is a probe consisting of a covalent Btk inhibitor chemically linked to biotin.
CSF1R-IN-2 Chemical Structure
 BCP40929 CSF1R-IN-2 2271119-26-5
TPX-0022, also known as CSF1R-IN-2, is an orally bioavailable multi-targeted kinase inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases.
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