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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
HIF-2a Translation Inhibitor 76 Chemical Structure
 BCP38668 HIF-2a Translation Inhibitor 76 882268-69-1
HIF-2a Translation Inhibitor 76 is a cell-permeable HIF-2a translation inhibitor (IC50 value 5 µM).
JND3229 Chemical Structure
 BCP38649 JND3229 2260886-64-2
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
Almonertinib Chemical Structure
 BCP38312 Almonertinib 1899921-05-1
Almonertinib is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.
Olmutinib dihydrochloride Chemical Structure
 BCP38296 Olmutinib dihydrochloride 1842366-97-5
Olmutinib is an orally available, mutant-selective third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that is being developed for treatment of advanced and metastatic EGFR mutation-positive non-small cell lung cancer (NSCLC).
CA-4948 Chemical Structure
 BCP33271 CA-4948 1801344-14-8
CA-4948 is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.
TP0463518 Chemical Structure
 BCP38229 TP0463518 1558021-37-0
TP0463518 is a novel prolyl hydroxylase (PHD) 1/2/3 pan inhibitor, inducing erythropoietin (EPO) production in both the kidney and liver, increasing the HIF-2α and EPO mRNA expression levels in the kidney cortex.
TL02-59 Chemical Structure
 BCP38228 TL02-59 1315330-17-6
TL02-59 is a novel potent and selective inhibitor of the myeloid Src-family kinase Fgr, suppressing AML cell growth in vitro and in vivo.
Epertinib hydrochloride Chemical Structure
 BCP37982 Epertinib hydrochloride 2071195-74-7
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4. It shows potent antitumor activity.
LDN-192960 dihydrochloride Chemical Structure
 BCP37917 LDN-192960 dihydrochloride 2309172-48-1
LDN-192960 is a potent and selective inhibitor of haspin.
TX1-85-1 Chemical Structure
 BCP37896 TX1-85-1 1603845-32-4
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).
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