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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
TAS0728 Chemical Structure
 BCP33300 TAS0728 2088323-16-2
TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33, 25, 86 and 36 nM for BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2, respectively. TAS0728 also inhibits the phosphorylation of HER2, HER3, and downstream effectors, shows no obvious effect on EGFR. Antitumor activity.
Pemigatinib Chemical Structure
 BCP31812 Pemigatinib 1513857-77-6
Pemigatinib is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
Pyrotinib Racemate Chemical Structure
 BCP36485 Pyrotinib Racemate 1246089-97-3
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
UNC2025 hydrochloride Chemical Structure
 BCP36467 UNC2025 hydrochloride UNC2025HCL
UNC-2025 hydrochloride is the hydrochloride salt of UNC-2025, which is the Mer/FLT3 dual inhibitor.
AZD7507 Chemical Structure
 BCP36143 AZD7507 1041852-85-0
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
PD173955-Analog1 Chemical Structure
 BCP36116 PD173955-Analog1 185039-99-0
PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
PF-04217903 phenolsulfonate Chemical Structure
 BCP36115 PF-04217903 phenolsulfonate 1159490-85-3
PF-04217903 phenolsulfonate is a potent ATP-competitive c-Met kinase inhibitor. It shows more than 1,000-fold selectivity relative to 208 kinases.PF-04217903 is a potent ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM for human c-Met.
AZD-4205 Chemical Structure
 BCP36112 AZD-4205 2091134-68-6
AZD4205 is a novel potent and selective janus kinase 1 (JAK1) inhibitor.
Acrizanib Chemical Structure
 BCP36110 Acrizanib 1229453-99-9
Acrizanib is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-KDR.
tBID Chemical Structure
 BCP36081 tBID 1639895-85-4
tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of  0.33 µM.
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