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ATM/ATR

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ATM/ATR

Chemical Structure Cat. No. Product Name CAS No.
KU 60019 Chemical Structure
 BCP30241 KU 60019 925701-46-8
KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
ATR inhibitor 1 Chemical Structure
 BCP23596 ATR inhibitor 1 1613200-51-3
AZ32 Chemical Structure
 BCP29590 AZ32 AZ32
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
AZ-31 Chemical Structure
 BCP29471 AZ-31 2088113-98-6
AZ-31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.
Mirin Chemical Structure
 BCP17184 Mirin 1198097-97-0
Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex.
NU 6027 Chemical Structure
 BCP09221 NU 6027 220036-08-8
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
IC-87114 Chemical Structure
 BCP01922 IC-87114 371242-69-2
IC-87114 was the first isoform-selective PI3K inhibitor.
BRD4770 Chemical Structure
 BCP10433 BRD4770 1374601-40-7
BRD4770 is a novel G9a(EHMT2) inhibitor with EC50 of 5 uM (trimethylated H3K9 in PANC-1 cell).
Bmh-21 Chemical Structure
 BCP13273 Bmh-21 896705-16-1
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.
AZ20 Chemical Structure
 BCP09895 AZ20 1233339-22-4
AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. AZ20 was discovered from a lead discovery and early optimization campaign from an mTOR inhibitor screening hit.
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