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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
BDA-366 Chemical Structure
BCP39785 BDA-366 1909226-00-1
BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high affinity and selectivity.
RO-5963 Chemical Structure
BCP39170 RO-5963 1416663-77-8
RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53.
S55746 Chemical Structure
BCP39114 S55746 1448584-12-0
S55746 is an orally available BCL-2 specific inhibitor (Ki = 1.3 nM), displaying 70 to 400-fold selectivity for BCL-2 over BCL-XL.
INCB086550 Chemical Structure
BCP38993 INCB086550 INCB086550
INCB086550, a first-in-class oral inhibitor of PD-L1, as initial immune checkpoint inhibitor therapy in participants with select solid tumors
GSK-963 Chemical Structure
BCP37994 GSK-963 2049868-46-2
GSK-963 is a potent and selective inhibitor of RIP1 kinase.
GSK962 Chemical Structure
BCP37995 GSK962 2049872-86-6
GSK962 is a negative control for GSK'963, a highly potent and selective RIP1 inhibitor.
GSK-843 Chemical Structure
BCP37845 GSK-843 1601496-05-2
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.
CRT5 Chemical Structure
BCP37818 CRT5 1034297-58-9
CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).
(Rac)-Benpyrine Chemical Structure
BCP37768 (Rac)-Benpyrine 1333714-43-4
(Rac)-Benpyrine is a racemate of Benpyrine. (Rac)-Benpyrine is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.
Ac-YVAD-CMK Chemical Structure
BCP37297 Ac-YVAD-CMK 178603-78-6
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1).
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