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Chemical Structure Cat. No. Product Name CAS No.
Gambogic Acid Chemical Structure
BCP21539 Gambogic Acid 2752-65-0
Gambogic Acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Methylthiouracil Chemical Structure
BCP21374 Methylthiouracil 56-04-2
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Embelin Chemical Structure
BCP31134 Embelin 550-24-3
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
PD-1-IN-17 Chemical Structure
BCP31132 PD-1-IN-17 1673560-66-1
PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM.
VU661013 Chemical Structure
BCP31022 VU661013 2131184-57-9
VU661013 is a potent and selective MCL-1 inhibitor.
TW-37 Chemical Structure
BCP27702 TW-37 877877-35-5
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
GSK3145095 Chemical Structure
BCP31015 GSK3145095 1622849-43-7
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
AZD-5991 S-enantiomer Chemical Structure
BCP30973 AZD-5991 S-enantiomer 2143061-82-7
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991.
AZD5991 Chemical Structure
BCP30972 AZD5991 2143061-81-6
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
NSC-207895 Chemical Structure
BCP23434 NSC-207895 58131-57-0
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
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