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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
Milademetan tosylate monohydrate Chemical Structure
BCP31919 Milademetan tosylate monohydrate 2095625-97-9
Milademetan (DS-3032b) is a novel potent MDM2 inhibitor that inhibits MDM2-p53 interaction with an IC50 of 5.57 nM in the HTRF assay.
BI-3812 Chemical Structure
BCP31903 BI-3812 2166387-64-8
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
Imidazole ketone erastin Chemical Structure
BCP31858 Imidazole ketone erastin 1801530-11-9
Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
BM-1197 Chemical Structure
BCP31671 BM-1197 1391107-89-3
BM-1197 is a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.
RHC80267 Chemical Structure
BCP31629 RHC80267 83654-05-1
RHC 80267 is a potent and selective inhibitor of diacylglycerol lipase
2-HBA Chemical Structure
BCP31469 2-HBA 131359-24-5
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
BMS-1166 hydrochloride Chemical Structure
BCP31309 BMS-1166 hydrochloride 2113650-05-6
BMS-1166 Hydrochloride is a potent PD-1/PD-L1 interaction inhibitor.
S29434 Chemical Structure
BCP31241 S29434 874484-20-5
S29434 is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
Gambogic Acid Chemical Structure
BCP21539 Gambogic Acid 2752-65-0
Gambogic Acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Methylthiouracil Chemical Structure
BCP21374 Methylthiouracil 56-04-2
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
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