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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
PK11007 Chemical Structure
BCP32609 PK11007 874146-69-7
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
(+)-Apogossypol Chemical Structure
BCP32267 (+)-Apogossypol 66389-74-0
(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
PK68 Chemical Structure
BCP32187 PK68 2173556-69-7
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis.
AZD-5991 Racemate Chemical Structure
BCP23513 AZD-5991 Racemate 2143010-83-5
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
Granzyme B Inhibitor Z-AAD-CH2Cl Chemical Structure
BCP29761 Granzyme B Inhibitor Z-AAD-CH2Cl Z-AAD-CH2Cl
Granzyme B Inhibitor Z-AAD-CH2Cl is a cell-permeable and irreversible inhibitor of granzyme B.
Granzyme B Inhibitor IV Chemical Structure
BCP29760 Granzyme B Inhibitor IV AC-IEPD-CHO
Granzyme B Inhibitor IV is a reversible inhibitor of granzyme B and caspase-8.
3-(Methylseleno)-L-alanine Chemical Structure
BCP30216 3-(Methylseleno)-L-alanine 26046-90-2
Se-methyl-L-selenocysteine is an L-alpha-amino acid compound having methylselanylmethyl as the side-chain. It has a role as an antineoplastic agent.
Milademetan tosylate monohydrate Chemical Structure
BCP31919 Milademetan tosylate monohydrate 2095625-97-9
Milademetan (DS-3032b) is a novel potent MDM2 inhibitor that inhibits MDM2-p53 interaction with an IC50 of 5.57 nM in the HTRF assay.
BI-3812 Chemical Structure
BCP31903 BI-3812 2166387-64-8
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
Imidazole ketone erastin Chemical Structure
BCP31858 Imidazole ketone erastin 1801530-11-9
Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
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