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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
2-HBA Chemical Structure
BCP31469 2-HBA 131359-24-5
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
BMS-1166 hydrochloride Chemical Structure
BCP31309 BMS-1166 hydrochloride 2113650-05-6
BMS-1166 Hydrochloride is a potent PD-1/PD-L1 interaction inhibitor.
S29434 Chemical Structure
BCP31241 S29434 874484-20-5
S29434 is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
Gambogic Acid Chemical Structure
BCP21539 Gambogic Acid 2752-65-0
Gambogic Acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Methylthiouracil Chemical Structure
BCP21374 Methylthiouracil 56-04-2
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Embelin Chemical Structure
BCP31134 Embelin 550-24-3
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
PD-1-IN-17 Chemical Structure
BCP31132 PD-1-IN-17 1673560-66-1
PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM.
VU661013 Chemical Structure
BCP31022 VU661013 2131184-57-9
VU661013 is a potent and selective MCL-1 inhibitor.
TW-37 Chemical Structure
BCP27702 TW-37 877877-35-5
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
GSK3145095 Chemical Structure
BCP31015 GSK3145095 1622849-43-7
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
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