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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
VU661013 Chemical Structure
BCP31022 VU661013 2131184-57-9
VU661013 is a potent and selective MCL-1 inhibitor.
TW-37 Chemical Structure
BCP27702 TW-37 877877-35-5
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
GSK3145095 Chemical Structure
BCP31015 GSK3145095 1622849-43-7
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
AZD-5991 S-enantiomer Chemical Structure
BCP30973 AZD-5991 S-enantiomer 2143061-82-7
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991.
AZD5991 Chemical Structure
BCP30972 AZD5991 2143061-81-6
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
NSC-207895 Chemical Structure
BCP23434 NSC-207895 58131-57-0
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
UAMC-3203 hydrochloride Chemical Structure
BCP30942 UAMC-3203 hydrochloride 2271358-65-5
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.
BTSA 1 Chemical Structure
BCP30923 BTSA 1 314761-14-3
BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
Tinoridine Chemical Structure
BCP12825 Tinoridine 24237-54-5
Tinoridine, also known as Y-3642, is a non-steroidal anti-inflammatory drug.
Tinoridine hydrochloride Chemical Structure
BCP30905 Tinoridine hydrochloride 25913-34-2
Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.
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