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mTOR

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mTOR

Chemical Structure Cat. No. Product Name CAS No.
XL-765 Chemical Structure
 BCP32612 XL-765 1123889-87-1
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
BGT226 Chemical Structure
 BCP26216 BGT226 915020-55-2
BGT226 is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
WYE-687 Chemical Structure
 BCP23427 WYE-687 1062161-90-3
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
3BDO Chemical Structure
 BCP29764 3BDO 890405-51-3
3BDO is a new mTOR activator which can also inhibit autophagy.
GNE-490 Chemical Structure
 BCP21623 GNE-490 1033739-92-2
GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR.
GNE-317 Chemical Structure
 BCP23939 GNE-317 1394076-92-6
GNE-317 is a PI3K/mTOR inhibitor, is able to cross the blood-brain barrier (BBB).
PQR530 Chemical Structure
 BCP20879 PQR530 1927857-61-1
PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity.
LY 303511 Chemical Structure
 BCP08239 LY 303511 154447-38-8
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
LY 303511 hydrochloride Chemical Structure
 BCP25465 LY 303511 hydrochloride LY303511HCl
LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K.
NSC781406 Chemical Structure
 BCP20676 NSC781406 1676893-24-5
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
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