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mTOR

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mTOR

Chemical Structure Cat. No. Product Name CAS No.
MTI-31 Chemical Structure
 BCP36715 MTI-31 1567915-38-1
MTI-31 is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
PI-103 Hydrochloride Chemical Structure
 BCP36117 PI-103 Hydrochloride 371935-79-4
PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.
Rapalink-1 Chemical Structure
 BCP33282 Rapalink-1 Rapalink-1
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker.
AZD8055 Fumaric acid Chemical Structure
 BCP25958 AZD8055 Fumaric acid 1201799-05-4
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
AZD8055 D(-)-Tartaric Acid Chemical Structure
 BCP25959 AZD8055 D(-)-Tartaric Acid 1201799-04-3
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
mTOR inhibitor-1 Chemical Structure
 BCP32690 mTOR inhibitor-1 468747-17-3
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
XL-765 Chemical Structure
 BCP32612 XL-765 1123889-87-1
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
BGT226 Chemical Structure
 BCP26216 BGT226 915020-55-2
BGT226 is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
WYE-687 Chemical Structure
 BCP23427 WYE-687 1062161-90-3
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
3BDO Chemical Structure
 BCP29764 3BDO 890405-51-3
3BDO is a new mTOR activator which can also inhibit autophagy.
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