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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
Necitumumab Chemical Structure
BCP30497 Necitumumab 906805-06-9
Necitumumab is a recombinant human IgG1 monoclonal antibody used as an antineoplastic.
TAS6417 Chemical Structure
BCP30474 TAS6417 1661854-97-2
TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
BMS-986165 Chemical Structure
BCP30443 BMS-986165 1609392-27-9
BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
Abrocitinib Chemical Structure
BCP30441 Abrocitinib 1622902-68-4
Abrocitinib, also known as PF-04965842, is an oral Janus Kinase 1 inhibitor being investigated for treatment of plaque psoriasis.
Lazertinib Chemical Structure
BCP30440 Lazertinib 1903008-80-9
Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.
AST2818 mesylate Chemical Structure
BCP30340 AST2818 mesylate 2130958-55-1
AST2818 mesylate is an EGFR inhibitor.
AST2818 Chemical Structure
BCP30339 AST2818 1869057-83-9
AST2818 is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.
JAK3-IN-6 Chemical Structure
BCP30249 JAK3-IN-6 1443235-95-7
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM.
NRC-2694 Chemical Structure
BCP30237 NRC-2694 936446-61-6
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.
AZD-8931 Difumaric acid Chemical Structure
BCP24789 AZD-8931 Difumaric acid 1196531-39-1
AZD-8931 is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.
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