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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
Theliatinib Chemical Structure
BCP31409 Theliatinib 1353644-70-8
Theliatinib is a potent, ATP-competitive and highly selective EGFR inhibitor, significantly inhibits phosphorylation of EGFR (p-EGFR) and its downstream targets, AKT and ERK (p-AKT and p-ERK), with anti-tumor activity. Theliatinib (HMPL-309) shows a Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively.
JND3229 Chemical Structure
BCP31299 JND3229 JND3229
JND3229 is a new highly potent EGFRC797S reversible inhibitor with IC50 value of 5.8 nM, and also potently suppressed EGFRL858R/T790M and EGFRWT with IC50 values of 30.5 and 6.8 nM.
Tyrphostin AG 490 Chemical Structure
BCP21393 Tyrphostin AG 490 134036-52-5
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Tyrphostin A46 Chemical Structure
BCP31172 Tyrphostin A46 122520-85-8
Tyrphostin A46 is an inhibitor of EGF receptor kinase with an IC50 value of 10 μM in the human epidermoid carcinoma cell line A431.
SMI-4a Chemical Structure
BCP21212 SMI-4a 327033-36-3
SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM against Pim-1 and 100 nM against Pim-2) with little or no activity against a panel of 58 other kinase.
PIM447 dihydrochloride Chemical Structure
BCP31128 PIM447 dihydrochloride 1820565-69-2
PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
Niclosamide Chemical Structure
BCP22958 Niclosamide 50-65-7
Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
TAK-788 Chemical Structure
BCP31045 TAK-788 AP32788
TAK-788 is a small, oral inhibitor of EGFR [epidermal growth factor receptor] and HER2 [human epidermal growth factor receptor 2].
Pim1/AKK1-IN-1 Chemical Structure
BCP27625 Pim1/AKK1-IN-1 1093222-27-5
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
WHI-P 97 Chemical Structure
BCP29062 WHI-P 97 211555-05-4
WHI-P97 is a rationally designed potent inhibitor of JAK-3.
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