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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
TAK-788 Chemical Structure
BCP31045 TAK-788 AP32788
TAK-788 is a small, oral inhibitor of EGFR [epidermal growth factor receptor] and HER2 [human epidermal growth factor receptor 2].
Pim1/AKK1-IN-1 Chemical Structure
BCP27625 Pim1/AKK1-IN-1 1093222-27-5
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
WHI-P 97 Chemical Structure
BCP29062 WHI-P 97 211555-05-4
WHI-P97 is a rationally designed potent inhibitor of JAK-3.
Avitinib maleate Chemical Structure
BCP19161 Avitinib maleate 1822357-78-7
Avitinib maleate, the maleate salt form of avitinib, is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) mutant-selective inhibitor(IC50= 7.68 nM), with potential antineoplastic activity.
Brevilin A Chemical Structure
BCP30982 Brevilin A 16503-32-5
Brevilin A, is a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. antitumour
Chrysophanic acid Chemical Structure
BCP23439 Chrysophanic acid 481-74-3
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
Tesevatinib Chemical Structure
BCP23438 Tesevatinib 781613-23-8
XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively.
ZD-4190 Chemical Structure
BCP30854 ZD-4190 413599-62-9
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.
LUT-014 Chemical Structure
BCP30636 LUT-014 2274819-46-2
LUT014 is a topical B-Raf Inhibitor, a proprietary, first-in-class, small molecule allowing administration of EGFR (Epidermal Growth Factor Receptor) Inhibitors to patients without interruptions caused by typical cutaneous side effects
Necitumumab Chemical Structure
BCP30497 Necitumumab 906805-06-9
Necitumumab is a recombinant human IgG1 monoclonal antibody used as an antineoplastic.
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