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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
TP-3654 Chemical Structure
BCP30070 TP-3654 1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
RX-518 Chemical Structure
BCP19075 RX-518 1660963-42-7
RX518 is an epidermal growth factor receptor (EGFR) inhibitor.
FM-381 Chemical Structure
BCP29350 FM-381 2226521-65-7
FM-381 is a Chemical Probe For JAK3 and JAK3 specific reversible covalent inhibitor.
TG46 Chemical Structure
BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
SB1317 Chemical Structure
BCP27919 SB1317 1204918-72-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
JNJ-26483327 Chemical Structure
BCP28258 JNJ-26483327 807640-87-5
JNJ-26483327 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
Oclacitinib maleate Chemical Structure
BCP28140 Oclacitinib maleate 1208319-27-0
Oclacitinib maleate is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).
PF-06700841 tosylate Chemical Structure
BCP29932 PF-06700841 tosylate 2140301-96-6
PF-06700841 is a potent, selective TYK2/JAK1 kinase inhibitor that reduces IL-23 expression and directly attenuates IL-23 signaling via TYK2.
PF-06700841 Chemical Structure
BCP29931 PF-06700841 1883299-62-4
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases.
Bayer-18 Chemical Structure
BCP21620 Bayer-18 1251752-12-1
Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays.
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