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Chemical Structure Cat. No. Product Name CAS No.
JND3229 Chemical Structure
BCP38649 JND3229 2260886-64-2
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
Almonertinib Chemical Structure
BCP38312 Almonertinib 1899921-05-1
Almonertinib is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells.
Epertinib hydrochloride Chemical Structure
BCP37982 Epertinib hydrochloride 2071195-74-7
Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4. It shows potent antitumor activity.
TX1-85-1 Chemical Structure
BCP37896 TX1-85-1 1603845-32-4
TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM).
PD089828 Chemical Structure
BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
EGFR-IN-8 Chemical Structure
BCP37628 EGFR-IN-8 2407957-87-1
EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48.
BDTX-189 Chemical Structure
BCP37532 BDTX-189 2414572-47-5
BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
CH7233163 Chemical Structure
BCP37295 CH7233163 CH7233163
CH7233163 overcomes osimertinib resistant EGFR-Del19/T790M/C797S mutation
Deuruxolitinib Chemical Structure
BCP36774 Deuruxolitinib 1513883-39-0
Pyrotinib Racemate Chemical Structure
BCP36485 Pyrotinib Racemate 1246089-97-3
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
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