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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
Pyrotinib Racemate Chemical Structure
BCP36485 Pyrotinib Racemate 1246089-97-3
Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
AZD-4205 Chemical Structure
BCP36112 AZD-4205 2091134-68-6
AZD4205 is a novel potent and selective janus kinase 1 (JAK1) inhibitor.
TAS6417 HCl Chemical Structure
BCP35916 TAS6417 HCl TAS6417HCl
TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
Gusacitinib hydrochloride Chemical Structure
BCP35707 Gusacitinib hydrochloride 2228989-14-6
Gusacitinib (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
TG-89 Chemical Structure
BCP35054 TG-89 936091-56-4
TG-89 is an inhibitor of JAK2, FLT3, RET and JAK3.
AG556 Chemical Structure
BCP35023 AG556 133550-41-1
AG-556 is an epidermal growth factor receptor (EGFR) kinase inhibitor.
Delgocitinib Chemical Structure
BCP34832 Delgocitinib 1263774-59-9
Delgocitinib is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
PF-06826647 Chemical Structure
BCP33615 PF-06826647 2127109-84-4
PF-06826647(Tyk2-IN-8) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.
Mobocertinib succinate Chemical Structure
BCP33315 Mobocertinib succinate 2389149-74-8
Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.
Norcantharidin Chemical Structure
BCP25426 Norcantharidin 29745-04-8
Norcantharidin is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
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