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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
TG-89 Chemical Structure
BCP35054 TG-89 936091-56-4
TG-89 is an inhibitor of JAK2, FLT3, RET and JAK3.
AG556 Chemical Structure
BCP35023 AG556 133550-41-1
AG-556 is an epidermal growth factor receptor (EGFR) kinase inhibitor.
Delgocitinib Chemical Structure
BCP34832 Delgocitinib 1263774-59-9
Delgocitinib is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
PF-06826647 Chemical Structure
BCP33615 PF-06826647 2127109-84-4
PF-06826647(Tyk2-IN-8) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.
Mobocertinib succinate Chemical Structure
BCP33315 Mobocertinib succinate 2389149-74-8
Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.
Norcantharidin Chemical Structure
BCP25426 Norcantharidin 29745-04-8
Norcantharidin is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
ONO7475 Chemical Structure
BCP33232 ONO7475 1646839-59-9
ONO-7475 is a potent and orally active Axl/Mer inhibitor. ONO-7475 targets and binds to both Axl and Mer, and prevents their activity.
STX-0119 Chemical Structure
BCP25956 STX-0119 851095-32-4
STX-0119 is a potent STAT3 inhibitor.
Tyrphostin AG30 Chemical Structure
BCP32895 Tyrphostin AG30 122520-79-0
Tyrphostin AG30 is an antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.
JBJ-04-125-02 Chemical Structure
BCP32863 JBJ-04-125-02 2060610-53-7
JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.
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