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Jak/Stat Pathway

Chemical Structure Cat. No. Product Name CAS No.
EGFR inhibitor Chemical Structure
BCP32602 EGFR inhibitor 879127-07-8
EGFR inhibitor is an EGFR inhibitor. It directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
FM-479 Chemical Structure
BCP32593 FM-479 2226521-64-6
FM-479 is a negative control for FM-381 (GLXC-09922).
Tarloxotinib bromide Chemical Structure
BCP32560 Tarloxotinib bromide 1636180-98-7
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor.
TCJL37 Chemical Structure
BCP32555 TCJL37 1258294-34-6
TCJL-37 is a potent TYK2 inhibitor.
Butein Chemical Structure
BCP31369 Butein 21849-70-7
Butein is a chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
BI-4020 Chemical Structure
BCP31931 BI-4020 BI4020
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). BI-4020 also shows activity against EGFR wt (IC50=190 nM). BI-4020 shows high kinome selectivity and good DMPK properties.
JBJ-04-125-02 Chemical Structure
BCP31914 JBJ-04-125-02 2140807-05-0
JBJ-04-125-02 is a single agent can inhibit cell proliferation and EGFRL858R/T790M/C797S signaling in vitro and in vivo.
TCS PIM-1 1 Chemical Structure
BCP15861 TCS PIM-1 1 491871-58-0
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
Gusacitinib HCl Chemical Structure
BCP31676 Gusacitinib HCl GusacitinibHCl
Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
Gusacitinib Chemical Structure
BCP31675 Gusacitinib 1425381-60-7
Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.
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