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Bcl2

Chemical Structure Cat. No. Product Name CAS No.
AMG176 Chemical Structure
 BCP25146 AMG176 1883727-34-1
AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities.
(-)BI97D6 Chemical Structure
 BCP25104 (-)BI97D6 1430067-36-9
The apogossypolone derivative -BI97D6 binds MCL1 and BCL2, BCL-XL, BFL1 with high affinities.
Sabutoclax Chemical Structure
 BCP20986 Sabutoclax 1228108-65-3
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.
AT-101 acetic acid Chemical Structure
 BCP24040 AT-101 acetic acid 866541-93-7
Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
CID5721353 Chemical Structure
 BCP18443 CID5721353 301356-95-6
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor).
BDA-366 Chemical Structure
 BCP17018 BDA-366 142645-19-0/1909226-00-1
BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high affinity and selectivity.
MIK 665 Chemical Structure
 BCP29223 MIK 665 1799631-75-6
MIK665, also known as S 64315, is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.
Aceticacidgossypol Chemical Structure
 BCP09006 Aceticacidgossypol 12542-36-8
Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
BH3I-1 Chemical Structure
 BCP17483 BH3I-1 300817-68-9
BH3I-1 is a Bcl-2 antagonist. BH3I-1 has a Kd of 5.3 μM against the p53/MDM2 pair.
FX1 Chemical Structure
 BCP20471 FX1 1426138-42-2
FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
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