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Bcl2

Chemical Structure Cat. No. Product Name CAS No.
(+)-Apogossypol Chemical Structure
 BCP32267 (+)-Apogossypol 66389-74-0
(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
AZD-5991 Racemate Chemical Structure
 BCP23513 AZD-5991 Racemate 2143010-83-5
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
BI-3812 Chemical Structure
 BCP31903 BI-3812 2166387-64-8
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
BM-1197 Chemical Structure
 BCP31671 BM-1197 1391107-89-3
BM-1197 is a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.
Gambogic Acid Chemical Structure
 BCP21539 Gambogic Acid 2752-65-0
Gambogic Acid is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
VU661013 Chemical Structure
 BCP31022 VU661013 2131184-57-9
VU661013 is a potent and selective MCL-1 inhibitor.
TW-37 Chemical Structure
 BCP27702 TW-37 877877-35-5
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
AZD-5991 S-enantiomer Chemical Structure
 BCP30973 AZD-5991 S-enantiomer 2143061-82-7
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991.
AZD5991 Chemical Structure
 BCP30972 AZD5991 2143061-81-6
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
BTSA 1 Chemical Structure
 BCP30923 BTSA 1 314761-14-3
BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
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