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Bcl2

Chemical Structure Cat. No. Product Name CAS No.
Bcl-2-IN-2 Chemical Structure
 BCP36375 Bcl-2-IN-2 2383085-86-5
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.
BCL2 Degrader C5 Chemical Structure
 BCP36383 BCL2 Degrader C5 2378801-85-3
BCL2 Degrader C5 is a novel potent and selective degrader of Bcl-2.
Marinopyrrole A Chemical Structure
 BCP36069 Marinopyrrole A 1227962-62-0
Marinopyrrole A is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
BDA-366 Chemical Structure
 BCP25061 BDA-366 1821496-27-8
BDA-366 is a Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.
Bz-423 Chemical Structure
 BCP25995 Bz-423 216691-95-1
Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.
ML311 Chemical Structure
 BCP32653 ML311 315698-17-0
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
(+)-Apogossypol Chemical Structure
 BCP32267 (+)-Apogossypol 66389-74-0
(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
AZD-5991 Racemate Chemical Structure
 BCP23513 AZD-5991 Racemate 2143010-83-5
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
BI-3812 Chemical Structure
 BCP31903 BI-3812 2166387-64-8
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
BM-1197 Chemical Structure
 BCP31671 BM-1197 1391107-89-3
BM-1197 is a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.
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