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Histone Demethylase

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Histone Demethylase

Chemical Structure Cat. No. Product Name CAS No.
KDOAM-25 Chemical Structure
BCP31703 KDOAM-25 2230731-99-2
KDOAM-25 is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.
GSK-467 Chemical Structure
BCP30840 GSK-467 1628332-52-4
GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1). GSK467 exploits unique binding modes.
T-3775440 Chemical Structure
BCP30535 T-3775440 1422620-34-5
T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
T-3775440 hydrochloride Chemical Structure
BCP30534 T-3775440 hydrochloride 1422535-52-1
T-3775440 hydrochloride is a potent, selecitve, irreversible LSD1 inhibitor.
Corin Chemical Structure
BCP30529 Corin 1808113-09-8
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
Tranylcypromine hemisulfate Chemical Structure
BCP15493 Tranylcypromine hemisulfate 13492-01-8
Tranylcypromine hemisulfate is an irreversible, nonselective MAO inhibitor used in the treatment of depression.
Seclidemstat Chemical Structure
BCP29581 Seclidemstat 1423715-37-0
Seclidemstat is an antineoplastic drug candidate.
AS-8351 Chemical Structure
BCP29140 AS-8351 796-42-9
AS-8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
KDM4B-IN-B3 Chemical Structure
BCP29547 KDM4B-IN-B3 2003260-55-5
KDM4B-IN-B3 is a potent KDM4B inhibitor with an IC50 of 10 nM.
OG-L002 Chemical Structure
BCP12278 OG-L002 1357302-64-7
OG-L002 is a potent LSD1 inhibitor that has been found to inhibit herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro and suppresses HSV primary infection in vivo.
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