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MEK/ERK

Chemical Structure Cat. No. Product Name CAS No.
JWG-071 Chemical Structure
BCP31627 JWG-071 2250323-50-1
JWG-071 is the first reported kinase-selective chemical probe for ERK5.
GW284543 Chemical Structure
BCP31359 GW284543 790186-68-4
GW284543 is a potent and selective MEK5 inhibitor with the potential for cancer treatment.
Methylthiouracil Chemical Structure
BCP21374 Methylthiouracil 56-04-2
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
RO5126766 Chemical Structure
BCP21067 RO5126766 946128-88-7
Ro 5126766 is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively).
TMCB Chemical Structure
BCP27716 TMCB 905105-89-7
TMCB is a dual-kinase inhibitor. It acts by inhibiting both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8).
D-87503 Chemical Structure
BCP27634 D-87503 800394-83-6
D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.
CC-90003 Chemical Structure
BCP23624 CC-90003 1621999-82-3
CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.
MK-8353 Chemical Structure
BCP23615 MK-8353 1184173-73-6
MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
Ulixertinib hydrochloride Chemical Structure
BCP30834 Ulixertinib hydrochloride 1956366-10-1
Ulixertinib hydrochloride is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.
Sodium Taurodeoxycholate Chemical Structure
BCP16412 Sodium Taurodeoxycholate 1180-95-6
Sodium taurodeoxycholate is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
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