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MEK/ERK

Chemical Structure Cat. No. Product Name CAS No.
Sodium Taurodeoxycholate Chemical Structure
BCP16412 Sodium Taurodeoxycholate 1180-95-6
Sodium taurodeoxycholate is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
Tauroursodeoxycholic acid sodium salt Chemical Structure
BCP14861 Tauroursodeoxycholic acid sodium salt 35807-85-3
Tauroursodeoxycholate Sodium is an ambiphilic bile acid that helps with liver and gallbladder issues.
LM22B-10 Chemical Structure
BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
KO947 HCl Chemical Structure
BCP29926 KO947 HCl KO947HCL
KO-947 is a potent and selective ERK inhibitor with slow dissociation kinetics.
FR 180204 Chemical Structure
BCP09857 FR 180204 865362-74-9
FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
XMD 8-92 Chemical Structure
BCP03605 XMD 8-92 1234480-50-2
XMD8-92 is highly selective ERK5/BMK1 inhibitor (KD values are 80, 190, 600 and 890 nM for BMK1, DCAMKL2, PLK4 and TNK1 respectively).
AZD-0364 Chemical Structure
BCP29508 AZD-0364 2097416-76-5
AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM.
RG7304 Chemical Structure
BCP28658 RG7304 213406-50-9
RG7304, also known as CK-127, is a MEK inhibitor currently in clinical trials.
XL-518 racemate Chemical Structure
BCP20611 XL-518 racemate 934662-91-6
Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of MEK1/2.
Cobimetinib R-enantiomer Chemical Structure
BCP20607 Cobimetinib R-enantiomer 934660-94-3
Cobimetinib (R-enantiomer) is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.
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