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TGF beta/Smad
BMP/TGF beta Receptor

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BMP/TGF beta Receptor

Chemical Structure Cat. No. Product Name CAS No.
BIO-013077-01 Chemical Structure
BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
SJ000291942 Chemical Structure
BCP29880 SJ000291942 425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
LDN-193189 2HCl Chemical Structure
BCP20431 LDN-193189 2HCl 1435934-00-1
LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively.
A 77-01 Chemical Structure
BCP13726 A 77-01 607737-87-1
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
LDN-214117 Chemical Structure
BCP12392 LDN-214117 1627503-67-6
LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity.
ML347 Chemical Structure
BCP09855 ML347 1062368-49-3
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
ITD-1 Chemical Structure
BCP15865 ITD-1 1099644-42-4
ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50 = 0.85 μM).
LDN-212854 Chemical Structure
BCP08633 LDN-212854 1432597-26-6
LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
DMH-1 Chemical Structure
BCP09856 DMH-1 1206711-16-1
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
K02288 Chemical Structure
BCP09946 K02288 1431985-92-0
Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively).
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