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BMP/TGF beta Receptor

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BMP/TGF beta Receptor

Chemical Structure Cat. No. Product Name CAS No.
SJ000291942 Chemical Structure
BCP29880 SJ000291942 425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
LDN-193189 2HCl Chemical Structure
BCP20431 LDN-193189 2HCl 1435934-00-1
LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively.
A 77-01 Chemical Structure
BCP13726 A 77-01 607737-87-1
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
LDN-214117 Chemical Structure
BCP12392 LDN-214117 1627503-67-6
LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity.
ML347 Chemical Structure
BCP09855 ML347 1062368-49-3
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
ITD-1 Chemical Structure
BCP15865 ITD-1 1099644-42-4
ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50 = 0.85 μM).
LDN-212854 Chemical Structure
BCP08633 LDN-212854 1432597-26-6
LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
DMH-1 Chemical Structure
BCP09856 DMH-1 1206711-16-1
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
K02288 Chemical Structure
BCP09946 K02288 1431985-92-0
Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively).
SD208 Chemical Structure
BCP02214 SD208 627536-09-8
TGF-β RI Kinase Inhibitor V is a selective and reversible inhibitor, which suppresses TGF-β RI/ALK5 signaling. It is known that TGF-β RI Kinase Inhibitor V also inhibits p38α at concentrations greater than 867 nM.
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