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GSK3

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GSK3

Chemical Structure Cat. No. Product Name CAS No.
Alsterpaullone Chemical Structure
BCP33241 Alsterpaullone 237430-03-4
Alsterpaullone, also known as 9-Nitropaullone and NSC 705701, is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).
CHIR-99021 trihydrochloride Chemical Structure
BCP26069 CHIR-99021 trihydrochloride 1782235-14-6
CHIR99021 is an orally active and potent GSK3 inhibitor. CHIR-73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR-73911 activates glycogen synthase in insulin receptorexpressing CHO-IR cells and primary rat hepatocyte
GNF4877 Chemical Structure
BCP31624 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM.
VP3.15 dihydrobromide Chemical Structure
BCP31222 VP3.15 dihydrobromide 1281681-33-1
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
VP3.15 Chemical Structure
BCP31223 VP3.15 1281681-54-6
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
ABC-1183 Chemical Structure
BCP30547 ABC-1183 1042735-18-1
ABC-1183 is a selective dual GSK3α/β and CKD9 inhibitor.
BIO-acetoxime Chemical Structure
BCP27976 BIO-acetoxime 667463-85-6
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.
CHIR-99021 HCl Chemical Structure
BCP26126 CHIR-99021 HCl 1797989-42-4
CHIR-99021 HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.
2-D08 Chemical Structure
BCP18314 2-D08 144707-18-6
2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation.
GSK-3 INHIBITOR XIII Chemical Structure
BCP12434 GSK-3 INHIBITOR XIII 404828-08-6
GSK-3 Inhibitor XIII is an aminopyrazole compound that acts as an ATP-binding site inhibitor of GSK-3.
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