Home   >  
Cell Cycle/DNA Damage
  • Epigenetics
  >  
Aurora

Classified by application

All Products

Signaling Pathways

Research Areas

Nature products

Antibodies

Peptides

Catalysts

Impurities

Intermediate

Raw Materials

Aurora

Chemical Structure Cat. No. Product Name CAS No.
Cenisertib Chemical Structure
BCP28083 Cenisertib 871357-89-0
Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer.
CCT241736 Chemical Structure
BCP29563 CCT241736 1402709-93-6
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
AT9283 Chemical Structure
BCP11714 AT9283 896466-04-9
AT9283 is a multi-targeted inhibitor with IC50s of 1.2 nM, 1.1 nM for JAK2 and JAK3, respectively, and is also potent to Aurora A, Aurora B and Abl(T315I).
ABT-348 Chemical Structure
BCP07256 ABT-348 1227939-82-3
ABT-348, is a novel potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials.
BI 847325 Chemical Structure
BCP15994 BI 847325 1207293-36-4
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
XL-228 Chemical Structure
BCP08143 XL-228 898280-07-4
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases.
ENMD-2076 Chemical Structure
BCP06358 ENMD-2076 934353-76-1
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.
ENMD-2076 Tartrate Chemical Structure
BCP14868 ENMD-2076 Tartrate 1291074-87-7
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
TAK-632 Chemical Structure
BCP08426 TAK-632 1228591-30-7
TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively.
SNS-314 Mesylate Chemical Structure
BCP24792 SNS-314 Mesylate 1146618-41-8
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
123下一页末页共 37 条记录 1 / 4 页 
0086-13720134139