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Aurora

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Aurora

Chemical Structure Cat. No. Product Name CAS No.
Cenisertib Chemical Structure
 BCP28083 Cenisertib 871357-89-0
Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine kinases which are important regulators of cell division and proliferation, and which are overexpressed in certain types of cancer.
CCT241736 Chemical Structure
 BCP29563 CCT241736 1402709-93-6
CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).
AT9283 Chemical Structure
 BCP11714 AT9283 896466-04-9
AT9283 is a multi-targeted inhibitor with IC50s of 1.2 nM, 1.1 nM for JAK2 and JAK3, respectively, and is also potent to Aurora A, Aurora B and Abl(T315I).
ABT-348 Chemical Structure
 BCP07256 ABT-348 1227939-82-3
ABT-348, is a novel potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials.
BI 847325 Chemical Structure
 BCP15994 BI 847325 1207293-36-4
BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
XL-228 Chemical Structure
 BCP08143 XL-228 898280-07-4
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases.
ENMD-2076 Chemical Structure
 BCP06358 ENMD-2076 934353-76-1
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.
ENMD-2076 Tartrate Chemical Structure
 BCP14868 ENMD-2076 Tartrate 1291074-87-7
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
TAK-632 Chemical Structure
 BCP08426 TAK-632 1228591-30-7
TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively.
SNS-314 Mesylate Chemical Structure
 BCP24792 SNS-314 Mesylate 1146618-41-8
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
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