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mGluR

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mGluR

Chemical Structure Cat. No. Product Name CAS No.
LY 379268 Chemical Structure
BCP27773 LY 379268 191471-52-0
LY 379268 is a highly selective group II mGlu receptor agonist with EC50 value of 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively.
JNJ40411813 Chemical Structure
BCP23709 JNJ40411813 1127498-03-6
JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor.
JNJ16259685 Chemical Structure
BCP23931 JNJ16259685 409345-29-5
JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
Raseglurant Chemical Structure
BCP24068 Raseglurant 757950-09-7
Raseglurant, aslo known as ADX-10059, is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety.
LSN2814617 Chemical Structure
BCP13851 LSN2814617 1313498-08-6
LSN2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
Lu AF21934 Chemical Structure
BCP20740 Lu AF21934 1445605-23-1
Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
(±)-trans-ACPD Chemical Structure
BCP18261 (±)-trans-ACPD 67684-64-4
trans-ACPD is a selective agonist for metabotropic glutamate receptors, acting at both group I and group II mGlu receptors.
JNJ-42153605 Chemical Structure
BCP28688 JNJ-42153605 1254977-87-1
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM.
E4CPG Chemical Structure
BCP18256 E4CPG 170846-69-6
E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .
FPTQ Chemical Structure
BCP18266 FPTQ 1025802-62-3
FPTQ is mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
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