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Chemical Structure Cat. No. Product Name CAS No.
PHCCC Chemical Structure
BCP25038 PHCCC 179068-02-1
PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.
Eglumetad Chemical Structure
BCP21205 Eglumetad 176199-48-7
Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.
VU-29 Chemical Structure
BCP27694 VU-29 890764-36-0
VU 29 is a potent allosteric potentiator at the rat mGlu5 receptor (EC50 = 9 nM); binds to the MPEP allosteric site (Ki app = 244 nM).
FITM Chemical Structure
BCP30765 FITM 932737-65-0
FITM is a potent mGlu1 inhibitor.
VU6012962 Chemical Structure
BCP30357 VU6012962 VU6012962
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.
LY 379268 Chemical Structure
BCP27773 LY 379268 191471-52-0
LY 379268 is a highly selective group II mGlu receptor agonist with EC50 value of 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively.
JNJ40411813 Chemical Structure
BCP23709 JNJ40411813 1127498-03-6
JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor.
JNJ16259685 Chemical Structure
BCP23931 JNJ16259685 409345-29-5
JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
Raseglurant Chemical Structure
BCP24068 Raseglurant 757950-09-7
Raseglurant, aslo known as ADX-10059, is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety.
LSN2814617 Chemical Structure
BCP13851 LSN2814617 1313498-08-6
LSN2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM).
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