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Thymidylate Synthase

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Thymidylate Synthase

Chemical Structure Cat. No. Product Name CAS No.
Nolatrexed dihydrochloride Chemical Structure
BCP02372 Nolatrexed dihydrochloride 152946-68-4
Nolatrexed dihydrochloride is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells.
Tipiracil HCl Chemical Structure
BCP06245 Tipiracil HCl 183204-72-0
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Tipiracil Chemical Structure
BCP24231 Tipiracil 183204-74-2
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
Raltitrexed Chemical Structure
BCP02874 Raltitrexed 112887-68-0
Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Trifluridine Chemical Structure
BCP09147 Trifluridine 70-00-8
Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
TAS-102 Chemical Structure
BCP28532 TAS-102 733030-01-8
TAS-102 is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase inhibitor, tipiracil, in a 1:0.5 molar ratio.
Nolatrexed Chemical Structure
BCP12638 Nolatrexed 147149-76-6
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity.
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