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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
BAY-299 Chemical Structure
 BCP41584 BAY-299 2080306-23-4
BAY-299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6 and 13 nM, respectively).
UMB298 Chemical Structure
 BCP41242 UMB298 2266569-73-5
UMB298 is a Potent and Selective CBP/P300 Inhibitor with CBP IC50= 72 nM.
SRX3207 Chemical Structure
 BCP40266 SRX3207 2254693-15-5
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively.
VZ185 Chemical Structure
 BCP38781 VZ185 2306193-61-1
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
VTP50469 fumarate Chemical Structure
 BCP38003 VTP50469 fumarate 2169919-29-1
VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
LP99 Chemical Structure
 BCP38006 LP99 1808951-93-0
LP99 is the First Selective BRD7/9 Bromodomain Inhibitor.
GSK9311 Chemical Structure
 BCP37781 GSK9311 1923851-49-3
GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively.
MS-402 Chemical Structure
 BCP37770 MS-402 1672684-68-2
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.
BAY1238097 Chemical Structure
 BCP37705 BAY1238097 1564268-08-1
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM).
PROTAC BET Degrader-10 Chemical Structure
 BCP36816 PROTAC BET Degrader-10 1957234-97-7
PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, with a DC50 of 49 nM.
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