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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
SNDX-5613 Chemical Structure
 BCP36044 SNDX-5613 2169919-21-3
SNDX-5613 is a potent and specific Menin-MLL inhibitor. It can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
MI-463 Chemical Structure
 BCP36072 MI-463 1628317-18-9
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.
MI-538 Chemical Structure
 BCP36073 MI-538 1857417-10-7
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.
GSK620 Chemical Structure
 BCP35923 GSK620 2088410-46-0
GSK620 is a novel BD2-selective BET inhibitor in vivo tool , binding to the individual tandem bromodomains [BD1 and BD2] of BRD2, BRD3, BRD4, and BRDT.
GSK046 Chemical Structure
 BCP35924 GSK046 2474876-09-8
GSK046 (iBET-BD2) is a selective and orally active inhibitor of BET, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
BRD4 Inhibitor-10 Chemical Structure
 BCP35872 BRD4 Inhibitor-10 1660117-38-3
BRD4 Inhibitor-10 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.
M-89 Chemical Structure
 BCP35588 M-89 2363165-42-6
M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.
Y06036 Chemical Structure
 BCP35043 Y06036 1832671-96-1
Y06036 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM. Antitumor activity.
MS31 Chemical Structure
 BCP34903 MS31 2366264-12-0
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3. It is not toxic to nontumorigenic cells.
VTP-50469 Chemical Structure
 BCP34837 VTP-50469 2169916-18-9
VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity.
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