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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
EBI-2511 Chemical Structure
 BCP30175 EBI-2511 2098546-05-3
EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.
UNC2400 Chemical Structure
 BCP08267 UNC2400 1433200-49-7
UNC2400 is a negative control for assays of UNC1999.
NI-57 Chemical Structure
 BCP17964 NI-57 1883548-89-7
NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively.
GSK8573 Chemical Structure
 BCP16859 GSK8573 1693766-04-9
GSK-8573 is the inactive control of GSK-2801.
A-485 Chemical Structure
 BCP26129 A-485 1889279-16-6
A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively.
GNE-272 Chemical Structure
 BCP19967 GNE-272 1936428-93-1
GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively.
MDK3597 Chemical Structure
 BCP30005 MDK3597 1505453-59-7
MDK3597 is a potent BET inhibitor extracted from patent WO/2015/153871A2, compound example 11.
Chemical Structure
ABBV-744 Chemical Structure
 BCP29855 ABBV-744 2138861-99-9
ABBV-744 is a highly BDII-selective BET bromodomain inhibitor, used in the research of inflammatory diseases, cancer, and AIDS.
CPI-268456 Chemical Structure
 BCP24103 CPI-268456 1380087-86-4
CPI-268456 is a potential BET bromodomain inhibitor.
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