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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
A1874 Chemical Structure
BCP32647 A1874 2064292-12-0
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells.
dBET57 Chemical Structure
BCP32540 dBET57 1883863-52-2
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2.
(R)-JQ-1 (carboxylic acid) Chemical Structure
BCP32538 (R)-JQ-1 (carboxylic acid) 202592-24-3
JQ1 Carboxylic Acid, also known as JQ1 Acid, is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
QCA570 Chemical Structure
BCP32101 QCA570 2207569-08-0
QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
OXFBD04 Chemical Structure
BCP31554 OXFBD04 OXFBD04
OXFBD04 shows improved BRD4(1) affinity (IC50 = 166 nM), optimised physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t½ = 388 min).
CBP-IN-1 Chemical Structure
BCP31464 CBP-IN-1 2222941-37-7
CBP-IN-1 is a potent p300/CBP bromodomain inhibitor.
MZ 1 Chemical Structure
BCP31482 MZ 1 1797406-69-9
MZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3.
GSK4027 Chemical Structure
BCP25140 GSK4027 2079896-25-4
GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
E-7386 Chemical Structure
BCP30544 E-7386 1799824-08-0
E-7386 is an orally active CBP/beta-catenin modulator.
INCB054329 Racemate Chemical Structure
BCP30528 INCB054329 Racemate 1628607-62-4
INCB054329 Racemate is a BET protein inhibitor.
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