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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
Alobresib Chemical Structure
BCP33313 Alobresib 1637771-14-2
Alobresib is an antineoplastic drug candidate.
UNC-926 Hydochloride Chemical Structure
BCP25396 UNC-926 Hydochloride 1782573-49-2
UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.
BETd-260 Chemical Structure
BCP33276 BETd-260 2093388-62-4
BETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
PF-CBP1 Chemical Structure
BCP32782 PF-CBP1 1962928-21-7
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.
A1874 Chemical Structure
BCP32647 A1874 2064292-12-0
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells.
dBET57 Chemical Structure
BCP32540 dBET57 1883863-52-2
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2.
(R)-JQ-1 (carboxylic acid) Chemical Structure
BCP32538 (R)-JQ-1 (carboxylic acid) 202592-24-3
JQ1 Carboxylic Acid, also known as JQ1 Acid, is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
QCA570 Chemical Structure
BCP32101 QCA570 2207569-08-0
QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
OXFBD04 Chemical Structure
OXFBD04 shows improved BRD4(1) affinity (IC50 = 166 nM), optimised physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t½ = 388 min).
CBP-IN-1 Chemical Structure
BCP31464 CBP-IN-1 2222941-37-7
CBP-IN-1 is a potent p300/CBP bromodomain inhibitor.
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