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Epigenetic Reader Domain

Chemical Structure Cat. No. Product Name CAS No.
OXFBD04 Chemical Structure
 BCP31554 OXFBD04 OXFBD04
OXFBD04 shows improved BRD4(1) affinity (IC50 = 166 nM), optimised physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t½ = 388 min).
CBP-IN-1 Chemical Structure
 BCP31464 CBP-IN-1 2222941-37-7
CBP-IN-1 is a potent p300/CBP bromodomain inhibitor.
MZ 1 Chemical Structure
 BCP31482 MZ 1 1797406-69-9
MZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3.
GSK4027 Chemical Structure
 BCP25140 GSK4027 2079896-25-4
GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
E-7386 Chemical Structure
 BCP30544 E-7386 1799824-08-0
E-7386 is an orally active CBP/beta-catenin modulator.
INCB054329 Racemate Chemical Structure
 BCP30528 INCB054329 Racemate 1628607-62-4
INCB054329 Racemate is a BET protein inhibitor.
(S)-JQ-35 Chemical Structure
 BCP30522 (S)-JQ-35 1349719-98-7
(S)-JQ-35 is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.
PROTAC BRD9 Degrader-1 Chemical Structure
 BCP30517 PROTAC BRD9 Degrader-1 2097971-01-0
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology.
PROTAC BET Degrader-1 Chemical Structure
 BCP30516 PROTAC BET Degrader-1 2093386-22-0
PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.
BRD4 degrader AT1 Chemical Structure
 BCP30515 BRD4 degrader AT1 2098836-45-2
BRD4 degrader AT1 is an analogue of MZ1. It shows improved selectivity for BRD4 degradation.
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