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ALK

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ALK

Chemical Structure Cat. No. Product Name CAS No.
TPX-0131 Chemical Structure
 BCP42131 TPX-0131 2648641-36-3
TPX-0131 is a CNS-penetrant, next-generation ALK inhibitor that has potency against wild-type ALK and a spectrum of acquired resistance mutations, especially the G1202R solvent front mutation and compound mutations, for which there are currently no effective therapies.
TL13-12 Chemical Structure
 BCP36914 TL13-12 2229037-04-9
TL13-12 is a novel selective anaplastic lymphoma kinase (ALK) degrader.
TL13-112 Chemical Structure
 BCP36884 TL13-112 2229037-19-6
TL13-112 shows chemically induced degradation of anaplastic lymphoma kinase (ALK).
MS4078 Chemical Structure
 BCP32539 MS4078 2229036-62-6
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 19 nM for binding affinity to ALK.
SAR348830 Chemical Structure
 BCP31069 SAR348830 1462949-64-9
SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).
BIBF0775 Chemical Structure
 BCP30371 BIBF0775 334951-90-5
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.
SM16 Chemical Structure
 BCP30149 SM16 614749-78-9
SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
BIO-013077-01 Chemical Structure
 BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
GW-6604 Chemical Structure
 BCP13570 GW-6604 452342-37-9
GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity.
Belizatinib Chemical Structure
 BCP29521 Belizatinib 1357920-84-3
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
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