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Angiogenesis/Protein Tyrosine Kinase

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Chemical Structure Cat. No. Product Name CAS No.
MS4078 Chemical Structure
BCP32539 MS4078 2229036-62-6
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 19 nM for binding affinity to ALK.
SAR348830 Chemical Structure
BCP31069 SAR348830 1462949-64-9
SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).
BIBF0775 Chemical Structure
BCP30371 BIBF0775 334951-90-5
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.
SM16 Chemical Structure
BCP30149 SM16 614749-78-9
SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
BIO-013077-01 Chemical Structure
BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
GW-6604 Chemical Structure
BCP13570 GW-6604 452342-37-9
GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity.
Belizatinib Chemical Structure
BCP29521 Belizatinib 1357920-84-3
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
Ensartinib  dihydrochloride Chemical Structure
BCP29059 Ensartinib dihydrochloride 2137030-98-7
Ensartinib, also known as X-396, is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
LDN-193189 2HCl Chemical Structure
BCP20431 LDN-193189 2HCl 1435934-00-1
LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively.
Alectinib Hydrochloride Chemical Structure
BCP09075 Alectinib Hydrochloride 1256589-74-8
Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with IC50 of 1.9 nM, the dissociation constant (KD) value for ALK in an ATP-competitive manner is 2.4 nM using a competition-bind assay.
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