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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
TMCB Chemical Structure
 BCP27716 TMCB 905105-89-7
TMCB is a dual-kinase inhibitor. It acts by inhibiting both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8).
LY2322600 Chemical Structure
 BCP27665 LY2322600 862505-01-9
LY2228820 is a novel and potent p38MAPK inhibitor.
D-87503 Chemical Structure
 BCP27634 D-87503 800394-83-6
D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.
CC-90003 Chemical Structure
 BCP23624 CC-90003 1621999-82-3
CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.
MK-8353 Chemical Structure
 BCP23615 MK-8353 1184173-73-6
MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
AT7867 dihydrochloride Chemical Structure
 BCP30936 AT7867 dihydrochloride 1431697-86-7
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
ETC206 Chemical Structure
 BCP30906 ETC206 1464151-33-4
ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
DMX-5084 Chemical Structure
 BCP30841 DMX-5084 2306178-56-1
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor.
MW-150 dihydrochloride dihydrate Chemical Structure
 BCP30837 MW-150 dihydrochloride dihydrate 1661020-92-3
MW-150 dihydrochloride dihydrate is a selective inhibitor of p38αMAPK isoform with a Ki of 101 nM.
Ulixertinib hydrochloride Chemical Structure
 BCP30834 Ulixertinib hydrochloride 1956366-10-1
Ulixertinib hydrochloride is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.
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