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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
GW284543 Chemical Structure
 BCP31359 GW284543 790186-68-4
GW284543 is a potent and selective MEK5 inhibitor with the potential for cancer treatment.
Belvarafenib Chemical Structure
 BCP31233 Belvarafenib 1446113-23-0
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
SL 0101-1 Chemical Structure
 BCP21457 SL 0101-1 77307-50-7
SL0101 is a highly specific RSK inhibitor. SL0101 showed improved in vitro biological stability while maintaining specificity for RSK. These results should facilitate the development of RSK inhibitors derived from SL0101 as anticancer agents.
TAK1/MAP4K2 inhibitor 1 Chemical Structure
 BCP21395 TAK1/MAP4K2 inhibitor 1 1315330-11-0
TAK1/MAP4K2 inhibitor 1 is a B-Raf inhibitor, pyrazine and pyrrolo[2,3-b]pyridine derivatives, useful in the treatment of cancer and proliferative diseases.
Methylthiouracil Chemical Structure
 BCP21374 Methylthiouracil 56-04-2
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
RO5126766 Chemical Structure
 BCP21067 RO5126766 946128-88-7
Ro 5126766 is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively).
TMCB Chemical Structure
 BCP27716 TMCB 905105-89-7
TMCB is a dual-kinase inhibitor. It acts by inhibiting both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8).
LY2322600 Chemical Structure
 BCP27665 LY2322600 862505-01-9
LY2228820 is a novel and potent p38MAPK inhibitor.
D-87503 Chemical Structure
 BCP27634 D-87503 800394-83-6
D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.
CC-90003 Chemical Structure
 BCP23624 CC-90003 1621999-82-3
CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.
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