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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
MW-150 Chemical Structure
 BCP34874 MW-150 1628502-91-9
MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM
OTS514 hydrochloride Chemical Structure
 BCP34816 OTS514 hydrochloride 2319647-76-0
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
5Z-7-Oxozeaenol Chemical Structure
 BCP34467 5Z-7-Oxozeaenol 253863-19-3
5Z-7-Oxozeaenol is a covalent inhibitor that acts against the several protein kinases (e.g. ERK2 and TAK1) that possess a free cysteine at the gatekeeper-2 position.
DTP3 TFA Chemical Structure
 BCP34038 DTP3 TFA DTP3
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor.
Donafenib Chemical Structure
 BCP34023 Donafenib 1130115-44-4
Donafenib is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib is under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC).
AS601245 Chemical Structure
 BCP32871 AS601245 345987-15-7
AS601245 is a cell-permeable JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively.
ERK5-IN-2 Chemical Structure
 BCP32587 ERK5-IN-2 1888305-96-1
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
Longdaysin Chemical Structure
 BCP32583 Longdaysin 1353867-91-0
Longdaysin is a novel inhibitor of CK1, ERK2, and CDK7 kinases.
SB 203580 hydrochloride Chemical Structure
 BCP29070 SB 203580 hydrochloride 869185-85-3
SB 203580 hydrochloride is a widely used p38 MAPK inhibitor. SB 203580 hydrochloride (RWJ 64809 hydrochloride) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 hydrochloride, but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
ASTX-029 Chemical Structure
 BCP32082 ASTX-029 2095719-92-7
ASTX029 is selective Inhibitor of Extracellular Signal-Related Protein Kinases 1 and 2 (ERK 1/2)
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