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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
Pexmetinib Chemical Structure
 BCP28410 Pexmetinib 945614-12-0
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
BRD32048 Chemical Structure
 BCP30330 BRD32048 433694-46-3
BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein.
LXH254 HCl Chemical Structure
 BCP30244 LXH254 HCl LXH254HCl
LXH254 is a potent CRAF inhibitor extracted from patent WO2018051306A1, Compound A. LXH254 also is a potent BRAF inhibitor.
Sodium Taurodeoxycholate Chemical Structure
 BCP16412 Sodium Taurodeoxycholate 1180-95-6
Sodium taurodeoxycholate is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
Tauroursodeoxycholic acid sodium salt Chemical Structure
 BCP14861 Tauroursodeoxycholic acid sodium salt 35807-85-3
Tauroursodeoxycholate Sodium is an ambiphilic bile acid that helps with liver and gallbladder issues.
LM22B-10 Chemical Structure
 BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
Carnosol Chemical Structure
 BCP20030 Carnosol 5957-80-2
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM.
OTS964(free base) Chemical Structure
 BCP17413 OTS964(free base) 1338540-81-0
OTS-964 is a potent TOPK inhibitor (IC50=28 nM), which inhibits TOPK kinase activity with high affinity and selectivity.
ML264 Chemical Structure
 BCP17456 ML264 1550008-55-3
ML 264 is a potent Krüppel-like factor 5 (KLF5) inhibitor
(Z)-Necrosulfonamide Chemical Structure
 BCP25934 (Z)-Necrosulfonamide 1360614-48-7
Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.
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