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MAPK Pathway

Chemical Structure Cat. No. Product Name CAS No.
AS601245 Chemical Structure
 BCP32871 AS601245 345987-15-7
AS601245 is a cell-permeable JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively.
ERK5-IN-2 Chemical Structure
 BCP32587 ERK5-IN-2 1888305-96-1
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
Longdaysin Chemical Structure
 BCP32583 Longdaysin 1353867-91-0
Longdaysin is a novel inhibitor of CK1, ERK2, and CDK7 kinases.
SB 203580 hydrochloride Chemical Structure
 BCP29070 SB 203580 hydrochloride 869185-85-3
SB 203580 hydrochloride is a widely used p38 MAPK inhibitor. SB 203580 hydrochloride (RWJ 64809 hydrochloride) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 hydrochloride, but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
ASTX-029 Chemical Structure
 BCP32082 ASTX-029 2095719-92-7
ASTX029 is selective Inhibitor of Extracellular Signal-Related Protein Kinases 1 and 2 (ERK 1/2)
SU 3327 Chemical Structure
 BCP32078 SU 3327 40045-50-9
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM) with selectivity over p38 MAPK and Akt. SU 3327 inhibits the interaction between JNK and JIP (IC50 = 239 nM).
AZ304 Chemical Structure
 BCP31900 AZ304 942507-42-8
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.
JWG-071 Chemical Structure
 BCP31627 JWG-071 2250323-50-1
JWG-071 is the first reported kinase-selective chemical probe for ERK5.
GW284543 Chemical Structure
 BCP31359 GW284543 790186-68-4
GW284543 is a potent and selective MEK5 inhibitor with the potential for cancer treatment.
Belvarafenib Chemical Structure
 BCP31233 Belvarafenib 1446113-23-0
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
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