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c Kit

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c Kit

Chemical Structure Cat. No. Product Name CAS No.
AMG-25 Chemical Structure
BCP20632 AMG-25 1003311-62-3
AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.
AST-487 Chemical Structure
BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
PLX3397 HCl Chemical Structure
BCP29551 PLX3397 HCl 2040295-03-0
PLX-3397 is a receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3, with potential antineoplastic activity, with IC50 of 28 and 16 nM for Fms and Kit, respectively.
DCC-2618 Chemical Structure
BCP29218 DCC-2618 1442472-39-0
DCC-2618 is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.
Sitravatinib Chemical Structure
BCP29099 Sitravatinib 1123837-84-2
Sitravatinib (MGCD516,MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
ISCK03 Chemical Structure
BCP20053 ISCK03 945526-43-2
ISCK03 is a specific SCF/c-Kit inhibitor.
AZD-2932 Chemical Structure
BCP07984 AZD-2932 883986-34-3
AZD2932 is a new series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
Flumatinib mesylate Chemical Structure
BCP08647 Flumatinib mesylate 895519-91-2
Flumatinib,a derivative of imatinib, is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively.
Flumatinib Chemical Structure
BCP23797 Flumatinib 895519-90-1
Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively.
AC-710 Chemical Structure
BCP14396 AC-710 1351522-04-7
AC710 is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively.
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