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HDAC

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HDAC

Chemical Structure Cat. No. Product Name CAS No.
Remetinostat Chemical Structure
 BCP30561 Remetinostat 946150-57-8
Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma.
Corin Chemical Structure
 BCP30529 Corin 1808113-09-8
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
Tinostamustine hydrochloride Chemical Structure
 BCP30456 Tinostamustine hydrochloride 1793059-58-1
Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule.
ACY-775 Chemical Structure
 BCP30179 ACY-775 1375466-18-4
ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.
Divalproex sodium Chemical Structure
 BCP12800 Divalproex sodium 76584-70-8
Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
HDAC-IN-6 Chemical Structure
 BCP13267 HDAC-IN-6 1026295-98-6
HDAC-IN-6 is an HDAC inhibitor, targeting HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9.
Apicidin Chemical Structure
 BCP13245 Apicidin 183506-66-3
Apicidin, a natural fugal metabolite, is a selective inhibitor of HDAC.
TH34 Chemical Structure
 BCP30033 TH34 2196203-96-8
TH34 is a potent HDAC6/8/10 inhibitor.
Tucidinostat Chemical Structure
 BCP29879 Tucidinostat 1616493-44-7
Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9.
Givinostat Chemical Structure
 BCP29856 Givinostat 497833-27-9
Givinostat is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
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