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HDAC

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HDAC

Chemical Structure Cat. No. Product Name CAS No.
Apicidin Chemical Structure
BCP13245 Apicidin 183506-66-3
Apicidin, a natural fugal metabolite, is a selective inhibitor of HDAC.
TH34 Chemical Structure
BCP30033 TH34 2196203-96-8
TH34 is a potent HDAC6/8/10 inhibitor.
Tucidinostat Chemical Structure
BCP29879 Tucidinostat 1616493-44-7
Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9.
Givinostat Chemical Structure
BCP29856 Givinostat 497833-27-9
Givinostat is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
MPI-5a Chemical Structure
BCP29593 MPI-5a 1259296-46-2
MPI-5a is a potent selective inhibitor of HDAC6, and poorly blocks other HDAC enzymes.
SR-​4370 Chemical Structure
BCP29031 SR-​4370 1816294-67-3
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
BRD6688 Chemical Structure
BCP17387 BRD6688 1404562-17-9
BRD6688 is a selective HDAC2 inhibitor. It acts by enhancing the learning and memory processes.
Splitomicin Chemical Structure
BCP10432 Splitomicin 5690-03-9
Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC.
R306465 Chemical Structure
BCP09101 R306465 604769-01-9
R306465, also known as JNJ-16241199, is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.
Citarinostat Chemical Structure
BCP09545 Citarinostat 1316215-12-9
Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.
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