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HDAC

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HDAC

Chemical Structure Cat. No. Product Name CAS No.
RGFP966 Chemical Structure
 BCP42941 RGFP966 1396841-57-8
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.
Resminostat hydrochloride Chemical Structure
 BCP39644 Resminostat hydrochloride 1187075-34-8
Resminostat HCl is a potent inhibitor of HDAC1/3/6.
SKLB-23bb Chemical Structure
 BCP37616 SKLB-23bb 1815580-06-3
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
Crotonoside Chemical Structure
 BCP34471 Crotonoside 1818-71-9
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.
Sinapic acid Chemical Structure
 BCP25316 Sinapic acid 530-59-6
Sinapic acid is found in american cranberry. Sinapic acid is a common constituent of plants and fruit.
Valproic acid Chemical Structure
 BCP33204 Valproic acid 99-66-1
Valproic acid is an inhibitor of histone deacetylase (HDAC) inhibitor, which has an anticancer effect. Valproic acid was shown to induce proliferation and enhance self-renewal of hematopoietic stem cells (HSC).
ACY-957 Chemical Structure
 BCP25969 ACY-957 1609389-52-7
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
CXD101 Chemical Structure
 BCP24800 CXD101 934828-12-3
CXD101 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. CXD101 has no activity against HDAC class II. CXD101 has antitumor activity.
SIS-17 Chemical Structure
 BCP31156 SIS-17 2374313-54-7
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Remetinostat Chemical Structure
 BCP30561 Remetinostat 946150-57-8
Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma.
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