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E1 E2 E3 Enzyme

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E1 E2 E3 Enzyme

Chemical Structure Cat. No. Product Name CAS No.
Thalidomide Chemical Structure
BCP19772 Thalidomide 50-35-1
Thalidomide is initially promoted as a sedative, inhibits ereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
TAME Chemical Structure
BCP02395 TAME 901-47-3
Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.
CC220 Chemical Structure
BCP20299 CC220 1323403-33-3
Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.
Suramin sodium Chemical Structure
BCP13783 Suramin sodium 129-46-4
Suramin sodium salt is a polysulfonated naphthylurea with various biological activities.
Tasisulam Chemical Structure
BCP05154 Tasisulam 519055-62-0
Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway.
ML792 Chemical Structure
BCP30807 ML792 1644342-14-2
ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.
PYZD 4409 Chemical Structure
BCP29044 PYZD 4409 423148-78-1
PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).
Indole-3-carbinol Chemical Structure
BCP00087 Indole-3-carbinol 700-06-1
Indole-3-carbinol suppresses NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist.
MDK-1699 Chemical Structure
BCP28593 MDK-1699 432001-69-9
MDK-1699, also known as Skp2 inhibitor C1 and SKPin C1, is a Skp2 inhibitor. MDK-1699 inhibits Skp2-mediated p27 degradation; induces cell cycle arrest.
NSC 600157 Chemical Structure
BCP17178 NSC 600157 31083-55-3
PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
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