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Nature products
Antibodies
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Raw Materials
TGF beta/Smad
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP38374 | Phorbol 12,13-dibutyrate New | 37558-16-0 |
Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter.
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BCP37871 | CMPD101 New | 865608-11-3 |
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
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BCP37563 | BMP signaling agonist sb4 New | 100874-08-6 |
BMP signaling agonist sb4 is a potent and selective BMP4 signaling agonist with EC50 value of 74 nM. It enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
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BCP34507 | Hispidin New | 555-55-5 |
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
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BCP34134 | TC-S 7001 New | 867017-68-3 |
TC-S 7001 is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively.
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BCP26044 | Y-27632 Dihydrochloride Hydrate New | 331752-47-7 |
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
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BCP14671 | LDN-212854 New | 143259726-6 |
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2.
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BCP32667 | VTX-27 New | 1321924-70-2 |
VTX-27 is a novel potent and selective PKCθ inhibitor.
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BCP32104 | 4alpha-PDD New | 27536-56-7 |
4alpha-PDD is a negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA). Though it is inactive for signaling through PKC, 4alpha-PDD has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.
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BCP31985 | CCG-222740 New | 1922098-69-8 |
CCG-222740 is a potent and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 also is a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.
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