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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
UCN-02 Chemical Structure
 BCP14344 UCN-02 121569-61-7
UCN-01 Chemical Structure
 BCP14345 UCN-01 112953-11-4
UCN-01 (7-hydroxystaurosporine) acts as an inhibitor against many phosphokinases, such as the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases.
Fasudil Chemical Structure
 BCP26821 Fasudil 103745-39-7
Fasudil, a Rho-kinase inhibitor, has been shown to reduce portal venous pressure in cirrhotic rats.
(+)-ITD-1 Chemical Structure
 BCP29917 (+)-ITD-1 1409968-46-2
(+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1.
Prostratin Chemical Structure
 BCP29895 Prostratin 60857-08-1
Prostratin is a protein kinase C activator. Inhibits growth and induces differentiation of AML cell lines.
Fasudil hydrochloride Chemical Structure
 BCP26351 Fasudil hydrochloride 105628-07-7
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Kis of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
SJ000291942 Chemical Structure
 BCP29880 SJ000291942 425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
Ingenol-3-angelate Chemical Structure
 BCP10402 Ingenol-3-angelate 75567-37-2
Ingenol-3-angelate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
BDP5290 Chemical Structure
 BCP29732 BDP5290 1817698-21-7
BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
RKI-1313 Chemical Structure
 BCP08342 RKI-1313 1342276-76-9
RKI-1313 Negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
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