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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
VK2809 Chemical Structure
 BCP30442 VK2809 VK2809
VK2809 is a small molecule orally available, tissue and receptor-subtype selective agonist of the thyroid beta receptor
LXS-196 2HCl Chemical Structure
 BCP30427 LXS-196 2HCl LXS-196HCl
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
MDK-8650 Chemical Structure
 BCP30378 MDK-8650 736048-65-0
MDK-8650 is a selective PKC-θinhibitor, with an IC50 of 12 nM.
SRI-011381 hydrochloride Chemical Structure
 BCP30374 SRI-011381 hydrochloride SRI011381HCl
SRI-011381 hydrochloride is a TGF-beta signaling agonist.
SRI-011381 Chemical Structure
 BCP30372 SRI-011381 1629138-41-5
SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
BLU-782 Chemical Structure
 BCP30344 BLU-782 2141955-96-4
BLU-782 (BLU782) is a novel potent, selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 nM.
Halofuginone Hydrobromide Chemical Structure
 BCP19376 Halofuginone Hydrobromide 64924-67-0
Halofuginone Hydrobromide is a potent prolyl-tRNA synthetase inhibitor.
SM16 Chemical Structure
 BCP30149 SM16 614749-78-9
SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
BIO-013077-01 Chemical Structure
 BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
PKC-IN-1 Chemical Structure
 BCP10410 PKC-IN-1 1046787-18-1
PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies.
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