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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
4alpha-PDD Chemical Structure
BCP32104 4alpha-PDD 27536-56-7
4alpha-PDD is a negative control for Phorbol-12,13-didecanoate (PDD) and Phorbol-12-myristate-13-acetate (PMA). Though it is inactive for signaling through PKC, 4alpha-PDD has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.
CCG-222740 Chemical Structure
BCP31985 CCG-222740 1922098-69-8
CCG-222740 is a potent and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 also is a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.
Ripasudil Hydrochloride Chemical Structure
BCP24238 Ripasudil Hydrochloride 223644-02-8
Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively.
GSK269962 Chemical Structure
BCP27824 GSK269962 850664-21-0
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK269962 can become an alternative worth considering in OAB treatment.
Glycyl-H 1152 dihydrochloride Chemical Structure
BCP27782 Glycyl-H 1152 dihydrochloride 913844-45-8
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC, respectively).
GSK 269962 trihydrochloride Chemical Structure
BCP26170 GSK 269962 trihydrochloride 925213-80-5
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively.
GSK269962 hydrochloride Chemical Structure
BCP26171 GSK269962 hydrochloride 2095432-71-4
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively.
Bisindoylmaleimide X Chemical Structure
BCP25395 Bisindoylmaleimide X 1241725-89-2
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
Fasudil hydrochloride hydrate Chemical Structure
BCP30939 Fasudil hydrochloride hydrate 186694-02-0
Fasudil, a potent inhibitor of ROCK with a Ki of 0.33 μM for ROCK1, which is also a potent Ca 2+ channel antagonist and vasodilator.
VK2809 Chemical Structure
BCP30442 VK2809 VK2809
VK2809 is a small molecule orally available, tissue and receptor-subtype selective agonist of the thyroid beta receptor
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