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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Halofuginone Hydrobromide Chemical Structure
BCP19376 Halofuginone Hydrobromide 64924-67-0
Halofuginone Hydrobromide is a potent prolyl-tRNA synthetase inhibitor.
SM16 Chemical Structure
BCP30149 SM16 614749-78-9
SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
BIO-013077-01 Chemical Structure
BCP30129 BIO-013077-01 746667-48-1
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
PKC-IN-1 Chemical Structure
BCP10410 PKC-IN-1 1046787-18-1
PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies.
Y 39983 dihydrochloride Chemical Structure
BCP18325 Y 39983 dihydrochloride 173897-44-4
Y-33075 dihydrochloride is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
TX-1918 Chemical Structure
BCP16358 TX-1918 503473-32-3
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
UCN-02 Chemical Structure
BCP14344 UCN-02 121569-61-7
UCN-01 Chemical Structure
BCP14345 UCN-01 112953-11-4
UCN-01 (7-hydroxystaurosporine) acts as an inhibitor against many phosphokinases, such as the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases.
Fasudil Chemical Structure
BCP26821 Fasudil 103745-39-7
Fasudil, a Rho-kinase inhibitor, has been shown to reduce portal venous pressure in cirrhotic rats.
(+)-ITD-1 Chemical Structure
BCP29917 (+)-ITD-1 1409968-46-2
(+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1.
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