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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Ripasudil Hydrochloride Chemical Structure
 BCP24238 Ripasudil Hydrochloride 223644-02-8
Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively.
GSK269962 Chemical Structure
 BCP27824 GSK269962 850664-21-0
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK269962 can become an alternative worth considering in OAB treatment.
Glycyl-H 1152 dihydrochloride Chemical Structure
 BCP27782 Glycyl-H 1152 dihydrochloride 913844-45-8
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC, respectively).
GSK 269962 trihydrochloride Chemical Structure
 BCP26170 GSK 269962 trihydrochloride 925213-80-5
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively.
GSK269962 hydrochloride Chemical Structure
 BCP26171 GSK269962 hydrochloride 2095432-71-4
GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively.
Bisindoylmaleimide X Chemical Structure
 BCP25395 Bisindoylmaleimide X 1241725-89-2
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
Fasudil hydrochloride hydrate Chemical Structure
 BCP30939 Fasudil hydrochloride hydrate 186694-02-0
Fasudil, a potent inhibitor of ROCK with a Ki of 0.33 μM for ROCK1, which is also a potent Ca 2+ channel antagonist and vasodilator.
VK2809 Chemical Structure
 BCP30442 VK2809 VK2809
VK2809 is a small molecule orally available, tissue and receptor-subtype selective agonist of the thyroid beta receptor
LXS-196 2HCl Chemical Structure
 BCP30427 LXS-196 2HCl LXS-196HCl
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
MDK-8650 Chemical Structure
 BCP30378 MDK-8650 736048-65-0
MDK-8650 is a selective PKC-θinhibitor, with an IC50 of 12 nM.
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