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JAK

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JAK

Chemical Structure Cat. No. Product Name CAS No.
Baricitinib trifluoroacetate Chemical Structure
 BCP16048 Baricitinib trifluoroacetate 1187594-10-0
Baricitinib, also known as INCB 028050 or LY 3009104, is an orally administered selective JAK1 andk JAK 2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK 2( 5.7 nM).
Ruxolitinib maleic acid salt Chemical Structure
 BCP30121 Ruxolitinib maleic acid salt 1092939-15-5
Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3.
Ruxolitinib sulfate Chemical Structure
 BCP27733 Ruxolitinib sulfate 1092939-16-6
Ruxolitinib sulfate is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
CEP33779 Chemical Structure
 BCP27756 CEP33779 1257704-57-6
CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
FM-381 Chemical Structure
 BCP29350 FM-381 2226521-65-7
FM-381 is a Chemical Probe For JAK3 and JAK3 specific reversible covalent inhibitor.
TG46 Chemical Structure
 BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
SB1317 Chemical Structure
 BCP27919 SB1317 1204918-72-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
Oclacitinib maleate Chemical Structure
 BCP28140 Oclacitinib maleate 1208319-27-0
Oclacitinib maleate is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).
PF-06700841 tosylate Chemical Structure
 BCP29932 PF-06700841 tosylate 2140301-96-6
PF-06700841 is a potent, selective TYK2/JAK1 kinase inhibitor that reduces IL-23 expression and directly attenuates IL-23 signaling via TYK2.
PF-06700841 Chemical Structure
 BCP29931 PF-06700841 1883299-62-4
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases.
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