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JAK

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JAK

Chemical Structure Cat. No. Product Name CAS No.
BMS-986165 Chemical Structure
 BCP30443 BMS-986165 1609392-27-9
BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
Abrocitinib Chemical Structure
 BCP30441 Abrocitinib 1622902-68-4
Abrocitinib, also known as PF-04965842, is an oral Janus Kinase 1 inhibitor being investigated for treatment of plaque psoriasis.
JAK3-IN-6 Chemical Structure
 BCP30249 JAK3-IN-6 1443235-95-7
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM.
Baricitinib trifluoroacetate Chemical Structure
 BCP16048 Baricitinib trifluoroacetate 1187594-10-0
Baricitinib, also known as INCB 028050 or LY 3009104, is an orally administered selective JAK1 andk JAK 2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK 2( 5.7 nM).
Ruxolitinib maleic acid salt Chemical Structure
 BCP30121 Ruxolitinib maleic acid salt 1092939-15-5
Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3.
Ruxolitinib sulfate Chemical Structure
 BCP27733 Ruxolitinib sulfate 1092939-16-6
Ruxolitinib sulfate is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
CEP33779 Chemical Structure
 BCP27756 CEP33779 1257704-57-6
CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
TG46 Chemical Structure
 BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
SB1317 Chemical Structure
 BCP27919 SB1317 1204918-72-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
Oclacitinib maleate Chemical Structure
 BCP28140 Oclacitinib maleate 1208319-27-0
Oclacitinib maleate is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).
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