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Angiogenesis/Protein Tyrosine Kinase
  • Jak/Stat Pathway
  • Wnt/Stem Cell
  • Epigenetics

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Chemical Structure Cat. No. Product Name CAS No.
TG46 Chemical Structure
BCP28052 TG46 936091-15-5
TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3.
SB1317 Chemical Structure
BCP27919 SB1317 1204918-72-8
SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 for the treatment of cancer, with IC50 of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively.
Oclacitinib maleate Chemical Structure
BCP28140 Oclacitinib maleate 1208319-27-0
Oclacitinib maleate is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).
PF-06700841 tosylate Chemical Structure
BCP29932 PF-06700841 tosylate 2140301-96-6
PF-06700841 is a potent, selective TYK2/JAK1 kinase inhibitor that reduces IL-23 expression and directly attenuates IL-23 signaling via TYK2.
PF-06700841 Chemical Structure
BCP29931 PF-06700841 1883299-62-4
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases.
Bayer-18 Chemical Structure
BCP21620 Bayer-18 1251752-12-1
Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays.
XL-019 Chemical Structure
BCP29586 XL-019 945750-13-0
XL019 is a potent JAK2 inhibitor (IC50 of 2 nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC50 of 130 nM; JAK3, IC50 of 250 nM; TYK2, IC50 of 340 nM).
NVP-BSK805 Chemical Structure
BCP29570 NVP-BSK805 1092499-93-8
NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
NVP-BSK805 2HCl Chemical Structure
BCP23423 NVP-BSK805 2HCl 1942919-79-0
NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.
RO495 Chemical Structure
BCP21626 RO495 1258296-60-4
RO495 is a very potent TYK2 inhibitor with a IC50 of 1.5nM on TYK2 as tested in cell-based pharmacological assays
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