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PI3K

Chemical Structure Cat. No. Product Name CAS No.
Nemiralisib Chemical Structure
BCP38658 Nemiralisib 1254036-71-9
Nemiralisib, also known as GSK2269557, is a highly potent and selective inhaled PI3Kδ inhibitor for the treatment of COPD.
SAR405 R enantiomer Chemical Structure
BCP37991 SAR405 R enantiomer 1946010-79-2
SAR405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.
CGS 15943 Chemical Structure
BCP37843 CGS 15943 104615-18-1
CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively).
Zandelisib Chemical Structure
BCP36800 Zandelisib 1401436-95-0
Zandelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, and antineoplastic.
PI-103 Hydrochloride Chemical Structure
BCP36117 PI-103 Hydrochloride 371935-79-4
PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.
Recilisib sodium Chemical Structure
BCP35048 Recilisib sodium 922139-31-9
Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
Alpelisib hydrochloride Chemical Structure
BCP34729 Alpelisib hydrochloride 1584128-91-5
Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively.
Parsaclisib Chemical Structure
BCP33523 Parsaclisib 1426698-88-5
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
MDK34597 Chemical Structure
BCP25529 MDK34597 371934-59-7
MDK34597 is a PI3K inhibitor.
Umbralisib hydrochloride Chemical Structure
BCP24682 Umbralisib hydrochloride 1532533-78-0
Umbralisib hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202 HCl is a potent PI3Kδ inhibitor.
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