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PI3K

Chemical Structure Cat. No. Product Name CAS No.
NVP-QAV-572 Chemical Structure
 BCP27906 NVP-QAV-572 957209-68-6
NVP-QAV-572 is a potent PI3K kianse inhibitor.
Sonolisib Chemical Structure
 BCP27666 Sonolisib 502632-66-8
Sonolisib is an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity.
D-106669 Chemical Structure
 BCP27662 D-106669 938444-93-0
D 106669 is a potent and selective PI3K inhibitor.
D-87503 Chemical Structure
 BCP27634 D-87503 800394-83-6
D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.
BGT226 Chemical Structure
 BCP26216 BGT226 915020-55-2
BGT226 is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
VPS34 inhibitor 1 Chemical Structure
 BCP24973 VPS34 inhibitor 1 1383716-46-8
VPS34 inhibitor 1 is a potent and selective inhibitor of VPS34 (IC50= 15 nM).
WYE-687 Chemical Structure
 BCP23427 WYE-687 1062161-90-3
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
CAY10505 Chemical Structure
 BCP23441 CAY10505 1218777-13-9
CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor, was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats.
AS-604850 Chemical Structure
 BCP23442 AS-604850 648449-76-7
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.
Leniolisib Chemical Structure
 BCP30455 Leniolisib 1354690-24-6
Leniolisib, also known CDZ173, is a potent phosphatidylinositol 3-kinase inhibitor (PI3K inhibitor).
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