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PI3K

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PI3K

Chemical Structure Cat. No. Product Name CAS No.
GDC-0077 Chemical Structure
 BCP25972 GDC-0077 2060571-02-8
GDC-0077 is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K.
SAR-260301 Chemical Structure
 BCP13808 SAR-260301 1260612-13-2
SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform.
AMG511(racemate) Chemical Structure
 BCP29922 AMG511(racemate) 1253571-11-7
AMG-511 is a potent and selective pan class I PI3K inhibitor exhibiting IC50 values of 8, 11, 2, and 6 nM against the PI3K β, α, β, and ≤ isoforms respectively.
LX-2343 Chemical Structure
 BCP28952 LX-2343 333745-53-2
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
GNE-490 Chemical Structure
 BCP21623 GNE-490 1033739-92-2
GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR.
NIBR-17 Chemical Structure
 BCP29594 NIBR-17 944396-88-7
NIBR-17 is a pan class I PI3K inhibitor with IC50 values of 1, 9.2, 9 and 20 nM respectively for PI3Kapha - delta.
TASP0415914 Chemical Structure
 BCP29582 TASP0415914 1292300-75-4
TASP0415914 is an orally potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitor for the treatment of inflammatory diseases.
2-D08 Chemical Structure
 BCP18314 2-D08 144707-18-6
2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation.
TG 100713 Chemical Structure
 BCP05993 TG 100713 925705-73-3
TG100713 is an inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively).
Nemiralisib HCl Chemical Structure
 BCP28624 Nemiralisib HCl 1254036-77-5
Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor.
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