TAS-115
| CAS号 | 1190836-34-0 | 货号 | BCP34014 |
| 中文名 | TAS-115 | ||
| 英文名 | TAS-115 | ||
| 中文别名 | |||
| 英文别名 | TAS 115, TAS115; Pamufetinib; | ||
| 分子式 | C27H23FN4O4S | 分子量 | 518.56 |
| 生物活性 | TAS-115 is a c-MET Inhibitor. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer-bearing mice. TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met VEGFR | ||
结构式
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