PSEM 89S TFA
| CAS No. | 1336913-03-1 | Cat. No. | BCP35173 |
| Name | PSEM 89S TFA | ||
| Synonyms | PSEM 89S; | ||
| Formula | C18H23F3N2O5 | M. Wt | 404.39 |
| Description | PSEM 89S TFA is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant. | ||
| Pathways | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| Targets | nAChR | ||
Structure
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