PD089828
| CAS号 | 179343-17-0 | 货号 | BCP37851 |
| 中文名 | PD089828 | ||
| 英文名 | PD089828 | ||
| 中文别名 | |||
| 英文别名 | PD-089828;PD 089828; | ||
| 分子式 | C18H18Cl2N6O | 分子量 | 405.28 |
| 生物活性 | PD089828 is a potent FGFR inhibitor, which inhibits human full-length fibroblast growth factor (FGF) receptor-1 (FGFR-1), platelet-derived growth factor (PDGF) receptor beta subunit (PDGFR-beta), Src nonreceptor tyrosine kinase (c-Src) and epidermal growth factor (EGF) receptor (EGFR) tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 0.15 +/- 0.02 (n = 4), 0.18 +/- 0.04 (n = 3), 1.76 +/- 0.28 (n = 4) and 5.47 +/- 0.78 (n = 6) microM, respectively. The results highlight the biological characteristics of PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects. The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | PDGFR EGFR FGFR | ||
结构式
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