3'-甲氧基鸟苷
| CAS号 | 10300-27-3 | 货号 | BCP38465 |
| 中文名 | 3'-甲氧基鸟苷 | ||
| 英文名 | 3'-O-methylguanosine | ||
| 中文别名 | 3-O-甲基鸟苷; | ||
| 英文别名 | 3'-O-methyl-Guanosine;Guanosine, 3'-O-methyl-;3-OMG; | ||
| 分子式 | C11H15N5O5 | 分子量 | 297.27 |
| 生物活性 | 3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis | ||
结构式
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