Hydrocortisone sodium succinate

CAS No.	125-04-2	Cat. No.	BCP38923
Name	Hydrocortisone sodium succinate
Synonyms	Hydrocortisone 21-hemisuccinate sodium salt;
Formula	C25H33NaO8	M. Wt	484.52

Description	Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.
Pathways	GPCR/G Protein
Targets	Glucocorticoid Receptor

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