GS-9901
| CAS号 | 1640247-87-5 | 货号 | BCP44115 |
| 中文名 | GS-9901 | ||
| 英文名 | GS-9901 | ||
| 中文别名 | |||
| 英文别名 | GS 9901; GS9901; | ||
| 分子式 | C22H17ClFN9O | 分子量 | 477.89 |
| 生物活性 | GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.). GS-9901 displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. GS-9901 demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans. The favorable in vitro and in vivo attributes of GS-9901 resulted in its selection as a development candidate. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | PI3K | ||
结构式
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