(Z)-替沃噻吨
| CAS号 | 3313-26-6 | 货号 | BCP48214 |
| 中文名 | (Z)-替沃噻吨 | ||
| 英文名 | (Z)-Thiothixene | ||
| 中文别名 | |||
| 英文别名 | CIS-Thiothixene; | ||
| 分子式 | C23H29N3O2S2 | 分子量 | 443.63 |
| 生物活性 | Thiothixene is a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | 5 HT Receptor/Serotonin Receptor | ||
结构式
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