AZD-2932
| CAS号 | 883986-34-3 | 货号 | BCP07984 |
| 中文名 | AZD-2932 | ||
| 英文名 | AZD-2932 | ||
| 中文别名 | |||
| 英文别名 | AZD2932;AZD 2932; | ||
| 分子式 | C24H25N5O4 | 分子量 | 447.49 |
| 生物活性 | The same C6 in vivo model was used to study tumor growth inhibition (TGI) with AZD2932. Twice daily oral dosing (b.i.d.) 10 h apart resulted in significant TGI of 64% for both 50 and 12.5 mg/kg doses on the day the control animals were terminated (day 22 on the graph). Most importantly, xenografts bearing non-PDGFR expressing tumor cells were also sensitive to AZD2932 treatment: growth of Calu-6 tumor was inhibited by 81% and 72% at 50 and 12.5 mg/kg b.i.d. (p <0.001) and LoVo tumors by 67% at 50 mg/kg b.i.d. (p <0.001). | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | PDGFR VEGFR c Kit FLT3 | ||
结构式
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