KU14R
| CAS No. | 189224-48-4 | Cat. No. | BCP06499 |
| Name | KU14R | ||
| Synonyms | KU-14R;KU 14R; | ||
| Formula | C13H14N2O | M. Wt | 214.26 |
| Description | KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Neuro Signaling Pathway | ||
| Targets | Imidazoline Receptor Insulin Receptor | ||
Structure
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