Cenisertib
  • 化学数据
CAS号 871357-89-0 货号 BCP28083
中文名 Cenisertib
英文名 Cenisertib
中文别名
英文别名 R763; R 763; R-763; AS703569; AS-703569; AS 703569; MSC1992371A;
分子式 C24H30FN7O 分子量 451.55
  • 用途
生物活性 Cenisertib, also known as AS-703569 or R763; is an orally bioavailable, synthetic, small-molecule multi-Aurora kinase inhibitor with potential antineoplastic activity. Cenisertib selectively binds to and inhibits multiple Aurora kinases (AKs), which may result in the inhibition of cell division and proliferation, and the induction of apoptosis in tumor cells that overexpress AKs. Overexpressed in certain tumor cell types, AKs, a family of serine-threonine kinases, are important regulators of cell division and proliferation that are involved in controlling chromatid segregation.
信号通路 Cell Cycle/DNA Damage Epigenetics 
靶 点 Aurora 

结构式

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