SKLB610
| CAS号 | 1125780-41-7 | 货号 | BCP28112 |
| 中文名 | SKLB610 | ||
| 英文名 | SKLB610 | ||
| 中文别名 | |||
| 英文别名 | SKLB-610; SKLB 610; | ||
| 分子式 | C21H16F3N3O3 | 分子量 | 415.37 |
| 生物活性 | SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | PDGFR VEGFR FGFR | ||
结构式
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