UNC2250
| CAS号 | 1493694-70-4 | 货号 | BCP09929 |
| 中文名 | UNC2250 | ||
| 英文名 | UNC2250 | ||
| 中文别名 | |||
| 英文别名 | UNC-2250;UNC 2250; | ||
| 分子式 | C24H36N6O2 | 分子量 | 440.58 |
| 生物活性 | UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional antitumor activity. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor | ||
结构式
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