PRT062607 HCl
| CAS号 | 1370261-97-4 | 货号 | BCP09980 |
| 中文名 | PRT062607 HCl | ||
| 英文名 | PRT062607 HCl | ||
| 中文别名 | |||
| 英文别名 | P505-15;PRT062607;PRT-062607;PRT 062607; | ||
| 分子式 | C19H23N9O.HCl | 分子量 | 429.91 |
| 生物活性 | in vitro: P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL [1]. PRT318 and P505-15 effectively antagonize CLL cell survival after BCR triggering and in nurse-like cell-co-cultures. Moreover, they inhibit BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. in vivo: Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Syk | ||
结构式
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