SAR125844
| CAS号 | 1116743-46-4 | 货号 | BCP28183 |
| 中文名 | SAR125844 | ||
| 英文名 | SAR125844 | ||
| 中文别名 | |||
| 英文别名 | SAR 125844; SAR-125844; | ||
| 分子式 | C25H23FN8O2S2 | 分子量 | 550.63 |
| 生物活性 | SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity. Upon intravenous administration, SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. SAR125844 displayed nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and the M1250T and Y1235D mutants. Broad biochemical profiling revealed that SAR125844 was highly selective for MET kinase. SAR125844 inhibits MET autophosphorylation in cell-based assays in the nanomolar range, and promotes low nanomolar proapoptotic and antiproliferative activities selectively in cell lines with MET gene amplification or pathway addiction. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met | ||
结构式
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