ICG-001
| CAS号 | 780757-88-2 | 货号 | BCP13217 |
| 中文名 | ICG-001 | ||
| 英文名 | ICG-001 | ||
| 中文别名 | |||
| 英文别名 | ICG 001;ICG001; | ||
| 分子式 | C33H32N4O4 | 分子量 | 548.64 |
| 生物活性 | After treatment with 25μM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells. ICG-001, can phenotypically rescue normal nerve growth factor (NGF) -induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/β-catenin signaling pathway on neurite outgrowth and neuronal differentiation. A recent study demonstrates that 5μM ICG-001 inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells. | ||
| 上下游产品 | 1422253-38-0（PRI-724） 847591-62-2（ICG-001） | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Wnt | ||
结构式
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