Zatebradine
| CAS No. | 85175-67-3 | Cat. No. | BCP16190 |
| Name | Zatebradine | ||
| Synonyms | UL-FS-49;UL-FS 49;UL-FS49; | ||
| Formula | C26H36N2O5 | M. Wt | 456.58 |
| Description | Zatebradine is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. Its IC50 value is 10 uM of 92% inhibition of the hHCN1. It reduced the activity of oriens-lacunosum moleculare interneurons in wild-type and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells. It is a specific bradycardic agent. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | HCN Channel | ||
Structure
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