UNC2025
| CAS号 | 1429881-91-3 | 货号 | BCP16544 |
| 中文名 | UNC2025 | ||
| 英文名 | UNC2025 | ||
| 中文别名 | |||
| 英文别名 | UNC-2025;UNC 2025; | ||
| 分子式 | C28H40N6O | 分子量 | 476.66 |
| 生物活性 | UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor FLT3 | ||
结构式
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