BMS-3
| CAS No. | 1338247-30-5 | Cat. No. | BCP17224 |
| Name | BMS-3 | ||
| Synonyms | BMS 3; BMS3; | ||
| Formula | C17H12Cl2F2N4OS | M. Wt | 429.27 |
| Description | BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | LIMK | ||
Structure
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