PF-3450074
| CAS No. | 1352879-65-2 | Cat. No. | BCP25843 |
| Name | PF-3450074 | ||
| Synonyms | PF74; PF-74; PF 74; PF 3450074; PF3450074; | ||
| Formula | C27H27N3O2 | M. Wt | 425.52 |
| Description | PF-3450074 (PF74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HIV | ||
Structure
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