ADU-S100铵盐
| CAS号 | 1638750-96-5 | 货号 | BCP29660 |
| 中文名 | ADU-S100铵盐 | ||
| 英文名 | ADU-S100 ammonium salt | ||
| 中文别名 | |||
| 英文别名 | MIW815 ammonium salt;ML RR-S2 CDA ammonium salt;STING-Inducer-1 ammonium salt; | ||
| 分子式 | C20H30N12O10P2S2 | 分子量 | 724.60 |
| 生物活性 | ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles; shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C; also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP; demonstrates profound anti-tumor efficacy in established B16 melanoma. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | STING | ||
结构式
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