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ADU-S100 ammonium salt 结构式

ADU-S100铵盐

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP29660CAS号 :1638750-96-5纯度:98%
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  • 基本信息与产品描述
CAS号 1638750-96-5 货号 BCP29660
中文名 ADU-S100铵盐
英文名 ADU-S100 ammonium salt
中文别名
英文别名 MIW815 ammonium salt;ML RR-S2 CDA ammonium salt;STING-Inducer-1 ammonium salt;
SMILES C1C2C(C(C(O2)N3C=NC4=C3N=CN=C4N)OP(=S)(OCC5C(C(C(O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)[S-])[O-])O.[NH4+].[NH4+]
化学名称
分子式 C20H30N12O10P2S2 分子量 724.60
纯度 98% 配送 惯例下常温包邮
产品描述 ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles; shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C; also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP; demonstrates profound anti-tumor efficacy in established B16 melanoma.
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