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CRM1

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CRM1

结构式 货号 产品名称 CAS号
Leptomycin B 结构式
 BCP35974 来普霉素B 87081-35-4
Leptomycin B is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
Selinexor E-isomer 结构式
 BCP32614 Selinexor E-isomer 1421923-86-5
Selinexor trans-isomer is a trans-isomer of Selinexor or KPT-330, which is a CRM1-selective inhibitor of nuclear export.
Eltanexor 结构式
 BCP24993 Eltanexor 1642300-52-4
Eltanexor(KPT-8602) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
Piperlongumine 结构式
 BCP13030 荜茇酰胺 20069-09-4
Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Verdinexor 结构式
 BCP11733 Verdinexor 1392136-43-4
Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus replication in vitro and in vivo.
KPT-276 结构式
 BCP09428 KPT-276 1421919-75-6
KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Selinexor 结构式
 BCP08966 塞利尼索 1393477-72-9
KPT-330 is an orally bioavailable selective CRM1 inhibitor.
KPT-185 结构式
 BCP08195 KPT-185 1333151-73-7
KPT-185 is a selective CRM1 inhibitor.
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