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MAPK Pathway

结构式 货号 产品名称 CAS号
KG5 结构式
BCP46930 KG5 877874-85-6
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
MAP4K4-IN-3 结构式
BCP46896 MAP4K4-IN-3 1811510-58-3
MAP4K4-IN-3 may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
ONC-201 Dihydrochloride 结构式
BCP46830 ONC-201 Dihydrochloride 1638178-82-1
ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
Brimapitide 结构式
BCP46470 布立匹肽 1445179-97-4
Brimapitide is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3).
MK2-IN-1hydrochloride 结构式
BCP46469 MK2-IN-1hydrochloride 1314118-94-9
MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.
PD184161 结构式
BCP46466 PD184161 212631-67-9
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
SM-7368 结构式
BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
MNK1/2-IN-5 结构式
BCP46296 MNK1/2-IN-5 1426928-20-2
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
SB-747651A 结构式
BCP46274 SB-747651A 607372-46-3
SB-747651A is a specific mitogen- and stress-activated kinase 1 (MSK1) inhibitor. SB-747651A can be used for the research of inflammation.
SB-747651A dihydrochloride 结构式
BCP46273 SB-747651A dihydrochloride 1781882-72-1
SB-747651A dihydrochloride is a potent MSK1 inhibitor; also inhibiting other AGC group kinases.
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