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MAPK Pathway

结构式 货号 产品名称 CAS号
Brimapitide 结构式
 BCP46470 布立匹肽 1445179-97-4
Brimapitide is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3).
MK2-IN-1hydrochloride 结构式
 BCP46469 MK2-IN-1hydrochloride 1314118-94-9
MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.
PD184161 结构式
 BCP46466 PD184161 212631-67-9
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior.
SM-7368 结构式
 BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
MNK1/2-IN-5 结构式
 BCP46296 MNK1/2-IN-5 1426928-20-2
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
SB-747651A 结构式
 BCP46274 SB-747651A 607372-46-3
SB-747651A is a specific mitogen- and stress-activated kinase 1 (MSK1) inhibitor. SB-747651A can be used for the research of inflammation.
SB-747651A dihydrochloride 结构式
 BCP46273 SB-747651A dihydrochloride 1781882-72-1
SB-747651A dihydrochloride is a potent MSK1 inhibitor; also inhibiting other AGC group kinases.
Zunsemetinib 结构式
 BCP43532 Zunsemetinib 1640282-42-3
Zunsemetinib, also knoiwn as ATI-450 and CDD450, is a potent MK2 Inhibitor. ATI-450 binds with high affinity to the interface of the p38MAPK-MK2 complex and selectively inhibits p38MAPK-catalysed phosphorylation of MK2 which stabilises the inactive conformation of MK2, and subsequently reduces inflammatory cytokine levels. ATI-450 specifically blocks the downstream MK2-mediated inflammatory drive on the p38 pathway and may therefore avoid the tachyphylaxis associated with p38 inhibitors.
PF-05381941 结构式
 BCP45842 PF-05381941 1474022-02-0
PF-05381941 is a novel potent dual TAK1/p38a inhibitor.
CMPD-1 结构式
 BCP45765 CMPD-1 41179-33-3
CMPD-1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.
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