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Src/Bcr Abl

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Src/Bcr Abl

结构式 货号 产品名称 CAS号
TPX-0046 结构式
BCP43814 TPX-0046 TPX0046
TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.
Vodobatinib 结构式
BCP43522 Vodobatinib 1388803-90-4
Vodobatinib, also known as K-0706, is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
CSF1R-IN-2 结构式
BCP40929 CSF1R-IN-2 2271119-26-5
TPX-0022, also known as CSF1R-IN-2, is an orally bioavailable multi-targeted kinase inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases.
KX2-391 Mesylate 结构式
BCP25173 KX2-391 Mesylate 1080645-95-9
Tirbanibulin, also known as KX-01 and KX2-391, is the first clinical Src inhibitor of the novel peptidomimetic class that targets the peptide substrate site of Src providing more specificity toward Src kinase.
TL02-59 结构式
BCP38228 TL02-59 1315330-17-6
TL02-59 is a novel potent and selective inhibitor of the myeloid Src-family kinase Fgr, suppressing AML cell growth in vitro and in vivo.
DGY-06-116 结构式
BCP37659 DGY-06-116 2556836-50-9
DGY-06-116 is an irreversible covalent, selective Src inhibitor.
PD173955-Analog1 结构式
BCP36116 PD173955-Analog1 185039-99-0
PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
CH6953755 结构式
BCP35548 CH6953755 2055918-71-1
CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo.
GMB-475 结构式
BCP31499 GMB-475 2490599-18-1:2489876-37-9
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.
TG 100572 Hydrochloride 结构式
BCP21364 TG 100572 Hydrochloride 867331-64-4
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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