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Gamma secretase

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Gamma secretase

结构式 货号 产品名称 CAS号
MRK 560 结构式
BCP43170 MRK 560 677772-84-8
MRK-560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
LY-411575 (isomer 1) 结构式
BCP43166 LY-411575 (isomer 1) 209984-58-7
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.
CHF 5074 结构式
BCP30410 CHF 5074 749269-83-8
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
PF-03084014 结构式
BCP28117 PF-03084014 865773-15-5
PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
LY900009 结构式
BCP27986 LY900009 209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
BMS299897 结构式
BCP06241 BMS299897 290315-45-6
BMS-299897 markedly reduced both brain and plasma Abeta in APP-YAC mice with ED(50) values of 86 and 22 mg/kg per os (po), respectively.
Gamma-Secretase Modulators 结构式
BCP12943 Gamma-Secretase Modulators 937812-80-1
Gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. Gamma-Secretase Modulators is useful for Alzheimer's disease.
NGP-555 结构式
BCP25746 NGP-555 1304630-27-0
NGP555 is a γ-secretase modulator.
L685458 结构式
BCP16163 L685458 292632-98-5
L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
γ-Secretase Inhibitor XXI 结构式
BCP02178 γ-Secretase Inhibitor XXI 209986-17-4
γ-Secretase Inhibitor XXI, Compound E is a cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC50 = 300 pM for Aβ40 in CHO cells overexpressing wild type βAPP.
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